Wnt2 complements Wnt/β-catenin signaling in colorectal cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Youn-Sang | - |
dc.contributor.author | Jun, Sohee | - |
dc.contributor.author | Lee, Sun Hye | - |
dc.contributor.author | Sharma, Amrish | - |
dc.contributor.author | Park, Jae-Il | - |
dc.date.accessioned | 2023-03-08T18:43:27Z | - |
dc.date.available | 2023-03-08T18:43:27Z | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64501 | - |
dc.description.abstract | Wnt2 is implicated in various human cancers. However, it remains unknown how Wnt2 is upregulated in human cancer and contributes to tumorigenesis. Here we found that Wnt2 is highly expressed in colorectal cancer (CRC) cells. In addition to co-expression of Wnt2 with Wnt/beta-catenin target genes in CRC, knockdown or knockout of Wnt2 significantly downregulates Wnt/beta-catenin target gene expression in CRC cells. Importantly, depletion or ablation of endogenous Wnt2 inhibits CRC cell proliferation. Similarly, neutralizing secreted Wnt2 reduces Wnt target gene expression and suppresses CRC cell proliferation. Conversely, Wnt2 increases cell proliferation of intestinal epithelial cells. Intriguingly, WNT2 expression is transcriptionally silenced by EZH2-mediated H3K27me3 histone modification in non-CRC cells, However, WNT2 expression is de-repressed by the loss of PRC2's promoter occupancy in CRC cells. Our results reveal the unexpected roles of Wnt2 in complementing Wnt/beta-catenin signaling for CRC cell proliferation. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.title | Wnt2 complements Wnt/β-catenin signaling in colorectal cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.18632/oncotarget.6133 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.6, no.35, pp 37257 - 37268 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000366113200025 | - |
dc.identifier.scopusid | 2-s2.0-84947747238 | - |
dc.citation.endPage | 37268 | - |
dc.citation.number | 35 | - |
dc.citation.startPage | 37257 | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 6 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Wnt | - |
dc.subject.keywordAuthor | beta-catenin | - |
dc.subject.keywordAuthor | Wnt2 | - |
dc.subject.keywordAuthor | colorectal cancer | - |
dc.subject.keywordPlus | EZH2 SUPPRESSES METHYLATION | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | E3 LIGASE | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | TUMORIGENESIS | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.