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Immune-mediated Liver Injury in Hepatitis B Virus Infection

Authors
Oh, In SooPark, Su-Hyung
Issue Date
Aug-2015
Publisher
KOREA ASSOC IMMUNOLOGISTS
Keywords
Hepatitis B Virus; Pathogenesis; Immune response
Citation
IMMUNE NETWORK, v.15, no.4, pp 191 - 198
Pages
8
Journal Title
IMMUNE NETWORK
Volume
15
Number
4
Start Page
191
End Page
198
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64506
DOI
10.4110/in.2015.15.4.191
ISSN
1598-2629
2092-6685
Abstract
Hepatitis B virus (HBV) is responsible for approximately 350 million chronic infections worldwide and is a leading cause of broad-spectrum liver diseases such as hepatitis, cirrhosis and liver cancer. Although it has been well established that adaptive immunity plays a critical role in viral clearance, the pathogenetic mechanisms that cause liver damage during acute and chronic HBV infection remain largely known. This review describes our current knowledge of the immune-mediated pathogenesis of HBV infection and the role of immune cells in the liver injury during hepatitis B.
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