Immune-mediated Liver Injury in Hepatitis B Virus Infection
- Authors
- Oh, In Soo; Park, Su-Hyung
- Issue Date
- Aug-2015
- Publisher
- KOREA ASSOC IMMUNOLOGISTS
- Keywords
- Hepatitis B Virus; Pathogenesis; Immune response
- Citation
- IMMUNE NETWORK, v.15, no.4, pp 191 - 198
- Pages
- 8
- Journal Title
- IMMUNE NETWORK
- Volume
- 15
- Number
- 4
- Start Page
- 191
- End Page
- 198
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64506
- DOI
- 10.4110/in.2015.15.4.191
- ISSN
- 1598-2629
2092-6685
- Abstract
- Hepatitis B virus (HBV) is responsible for approximately 350 million chronic infections worldwide and is a leading cause of broad-spectrum liver diseases such as hepatitis, cirrhosis and liver cancer. Although it has been well established that adaptive immunity plays a critical role in viral clearance, the pathogenetic mechanisms that cause liver damage during acute and chronic HBV infection remain largely known. This review describes our current knowledge of the immune-mediated pathogenesis of HBV infection and the role of immune cells in the liver injury during hepatitis B.
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