Spatial and temporal action of chicken primordial germ cells during initial migration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Kyung Soo | - |
dc.contributor.author | Lee, Hyung Chul | - |
dc.contributor.author | Kim, Hyun Jeong | - |
dc.contributor.author | Lee, Hyo Gun | - |
dc.contributor.author | Kim, Young Min | - |
dc.contributor.author | Lee, Hong Jo | - |
dc.contributor.author | Park, Young Hyun | - |
dc.contributor.author | Yang, Seo Yeong | - |
dc.contributor.author | Rengaraj, Deivendran | - |
dc.contributor.author | Park, Tae Sub | - |
dc.contributor.author | Han, Jae Yong | - |
dc.date.accessioned | 2023-03-08T19:21:25Z | - |
dc.date.available | 2023-03-08T19:21:25Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 1470-1626 | - |
dc.identifier.issn | 1741-7899 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64630 | - |
dc.description.abstract | In most animals, primordial germ cells (PGCs) originate from an extragonadal region and migrate across the embryo to the gonads, where they differentiate and function. During their migration, PGCs move passively by morphogenetic movement of the embryo or move actively through signaling molecules. To uncover the underlying mechanism of first-phase PGC migration toward the germinal crescent in chickens, we investigated the spatial and temporal action of PGCs during primitive streak formation. Exogenously transplanted PGCs migrated toward the anterior region of the embryo and the embryonic gonads when they were transplanted into the subgerminal cavity, but not into the posterior marginal zone, in Eyal-Giladi and Kochav stage X embryos. These results indicate that for passive migration toward the anterior region the initial location of PGCs should be the central region. Notably, although PGCs and DF-1 cells migrated passively toward the anterior region, only PGCs migrated to the germinal crescent, where endogenous PGCs mainly reside, by active movement. In a live-imaging experiment with green fluorescence protein-expressing transgenic embryos, exogenous PGCs demonstrated markedly faster migration when they reached the anterior one-third of the embryo, while somatic cells showed epiblast movement with constant speed. Also, migrating PGCs exhibited successive contraction and expansion indicating their active migration. Our results suggest that chicken PGCs use sequential passive and active forces to migrate toward the germinal crescent. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BIOSCIENTIFICA LTD | - |
dc.title | Spatial and temporal action of chicken primordial germ cells during initial migration | - |
dc.type | Article | - |
dc.identifier.doi | 10.1530/REP-14-0433 | - |
dc.identifier.bibliographicCitation | REPRODUCTION, v.149, no.2, pp 179 - 187 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000349476200009 | - |
dc.identifier.scopusid | 2-s2.0-84921296669 | - |
dc.citation.endPage | 187 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 179 | - |
dc.citation.title | REPRODUCTION | - |
dc.citation.volume | 149 | - |
dc.type.docType | Review | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | PRIMITIVE STREAK | - |
dc.subject.keywordPlus | EMBRYO | - |
dc.subject.keywordPlus | MORPHOLOGY | - |
dc.subject.keywordPlus | ORIGIN | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | GASTRULATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EPIBLAST | - |
dc.relation.journalResearchArea | Developmental Biology | - |
dc.relation.journalResearchArea | Reproductive Biology | - |
dc.relation.journalWebOfScienceCategory | Developmental Biology | - |
dc.relation.journalWebOfScienceCategory | Reproductive Biology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.