On the Estimation of Heritability with Family-Based and Population-Based Samples
DC Field | Value | Language |
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dc.contributor.author | Kim, Youngdoe | - |
dc.contributor.author | Lee, Young | - |
dc.contributor.author | Lee, Sungyoung | - |
dc.contributor.author | Kim, Nam Hee | - |
dc.contributor.author | Lim, Jeongmin | - |
dc.contributor.author | Kim, Young Jin | - |
dc.contributor.author | Oh, Ji Hee | - |
dc.contributor.author | Min, Haesook | - |
dc.contributor.author | Lee, Meehee | - |
dc.contributor.author | Seo, Hyeon-Jeong | - |
dc.contributor.author | Lee, So-Hyun | - |
dc.contributor.author | Sung, Joohon | - |
dc.contributor.author | Cho, Nam H. | - |
dc.contributor.author | Kim, Bong-Jo | - |
dc.contributor.author | Han, Bok-Ghee | - |
dc.contributor.author | Elston, Robert C. | - |
dc.contributor.author | Won, Sungho | - |
dc.contributor.author | Lee, Juyoung | - |
dc.date.accessioned | 2023-03-08T19:41:04Z | - |
dc.date.available | 2023-03-08T19:41:04Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.issn | 2314-6141 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64696 | - |
dc.description.abstract | For a family-based sample, the phenotypic variance-covariance matrix can be parameterized to include the variance of a polygenic effect that has then been estimated using a variance component analysis. However, with the advent of large-scale genomic data, the genetic relationship matrix (GRM) can be estimated and can be utilized to parameterize the variance of a polygenic effect for population-based samples. Therefore narrow sense heritability, which is both population and trait specific, can be estimated with both population-and family-based samples. In this study we estimate heritability from both family-based and population-based samples, collected in Korea, and the heritability estimates from the pooled samples were, for height, 0.60; body mass index (BMI), 0.32; log-transformed triglycerides (log TG), 0.24; total cholesterol (TCHL), 0.30; high-density lipoprotein (HDL), 0.38; low-density lipoprotein (LDL), 0.29; systolic blood pressure (SBP), 0.23; and diastolic blood pressure (DBP), 0.24. Furthermore, we found differences in how heritability is estimated-in particular the amount of variance attributable to common environment in twins can be substantial-which indicates heritability estimates should be interpreted with caution. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | HINDAWI LTD | - |
dc.title | On the Estimation of Heritability with Family-Based and Population-Based Samples | - |
dc.type | Article | - |
dc.identifier.doi | 10.1155/2015/671349 | - |
dc.identifier.bibliographicCitation | BIOMED RESEARCH INTERNATIONAL, v.2015 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000359544600001 | - |
dc.identifier.scopusid | 2-s2.0-84939512764 | - |
dc.citation.title | BIOMED RESEARCH INTERNATIONAL | - |
dc.citation.volume | 2015 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | TWIN-FAMILY | - |
dc.subject.keywordPlus | ALGORITHM | - |
dc.subject.keywordPlus | GENOMICS | - |
dc.subject.keywordPlus | TRAITS | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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