Combined application of camptothecin and the guanylate cyclase activator YC-1: Impact on cell death and apoptosis-related proteins in ovarian carcinoma cell lines
DC Field | Value | Language |
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dc.contributor.author | Lee, Sun-Joo | - |
dc.contributor.author | Kim, Yun Jeong | - |
dc.contributor.author | Lee, Chung Soo | - |
dc.contributor.author | Bae, Jaeman | - |
dc.date.accessioned | 2023-03-08T23:37:25Z | - |
dc.date.available | 2023-03-08T23:37:25Z | - |
dc.date.issued | 2009-10 | - |
dc.identifier.issn | 0009-2797 | - |
dc.identifier.issn | 1872-7786 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/65191 | - |
dc.description.abstract | Camptothecin analogs and guanylate cyclase activator YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] have been shown to induce apoptosis in cancer cells. However, the combined effect of camptothecin analogs and YC-1 on the viability of epithelial ovarian cancer cells remains uncertain. We assessed the combined effect of YC-1 on the camptothecin toxicity in the human epithelial ovarian carcinoma cell lines OVCAR-3 and SK-OV-3. Camptothecin and YC-1 induced apoptosis in OVCAR-3 and SK-OV-3 cells in a dose- and time-dependent manner. Both compounds induced nuclear damage, decreased Bid and Bcl-2 protein levels, enhanced cytochrome c release, activated caspase-3 and upregulated tumor suppressor p53. Camptothecin decreased Bax protein levels, whereas YC-1 increased Bax levels. YC-1 enhanced the camptothecin-induced changes in the apoptotic protein levels and increased apoptotic effect of camptothecin on ovarian carcinoma cell lines. The results suggested that YC-1 may enhance a camptothecin toxicity against ovarian carcinoma cell lines by increasing activation of the caspase-8 and Bid pathway as well as activation of the mitochondria-mediated apoptotic pathway, leading to cytochrome c release and subsequent caspase-3 activation. Combination of camptothecin analogs and YC-1 may provide a therapeutic benefit against ovarian adenocarcinoma. (C) 2009 Elsevier Ireland Ltd. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Combined application of camptothecin and the guanylate cyclase activator YC-1: Impact on cell death and apoptosis-related proteins in ovarian carcinoma cell lines | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.cbi.2009.05.013 | - |
dc.identifier.bibliographicCitation | CHEMICO-BIOLOGICAL INTERACTIONS, v.181, no.2, pp 185 - 192 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000270212800005 | - |
dc.identifier.scopusid | 2-s2.0-68849102152 | - |
dc.citation.endPage | 192 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 185 | - |
dc.citation.title | CHEMICO-BIOLOGICAL INTERACTIONS | - |
dc.citation.volume | 181 | - |
dc.type.docType | Article | - |
dc.publisher.location | 아일랜드 | - |
dc.subject.keywordAuthor | Camptothecin | - |
dc.subject.keywordAuthor | YC-1 | - |
dc.subject.keywordAuthor | Epithelial ovarian cancer cell lines | - |
dc.subject.keywordAuthor | Apoptotic proteins | - |
dc.subject.keywordAuthor | Cell death | - |
dc.subject.keywordPlus | DRUG-INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | COLON-CANCER CELLS | - |
dc.subject.keywordPlus | TOPOISOMERASE-I | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | BAX | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | TOPOTECAN | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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