Polymorphisms in interleukin 8 and its receptors (IL8, IL8RA and IL8RB) and association of common IL8 receptor variants with peripheral blood eosinophil counts
DC Field | Value | Language |
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dc.contributor.author | Cheong, Hyun Sub | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Lee, Soo Ok | - |
dc.contributor.author | Park, Byung Lae | - |
dc.contributor.author | Choi, Yoo Hyun | - |
dc.contributor.author | Lim, Gun Il | - |
dc.contributor.author | Uh, Soo Taek | - |
dc.contributor.author | Kim, Young Hun | - |
dc.contributor.author | Lee, Jong-Young | - |
dc.contributor.author | Lee, Jong-Keuk | - |
dc.contributor.author | Kim, Hung Tae | - |
dc.contributor.author | Ryu, Ha-Jung | - |
dc.contributor.author | Kim, Ka-Kyung | - |
dc.contributor.author | Han, Bok Ghee | - |
dc.contributor.author | Kim, Jun Woo | - |
dc.contributor.author | Kimm, Kuchan | - |
dc.contributor.author | Oh, Bermseok | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.date.accessioned | 2023-03-09T00:31:25Z | - |
dc.date.available | 2023-03-09T00:31:25Z | - |
dc.date.issued | 2006-09 | - |
dc.identifier.issn | 1434-5161 | - |
dc.identifier.issn | 1435-232X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/65417 | - |
dc.description.abstract | Airway inflammation is a major factor in the pathogenesis of asthma. Interleukin 8 (IL8) is a potent proinflammatory cytokine that interacts with its receptors, IL8RA and IL8RB. We investigated the genetic polymorphisms in IL8, IL8RA, and IL8RB for any association with risk of asthma and peripheral blood eosinophil counts in a Korean population. By carrying out direct sequencing in 24 individuals, we identified 20 sequence variants within exons and their flanking regions, including the 1.5 kb promoter regions of IL8, IL8RA, and IL8RB. Among them, seven common single-nucleotide polymorphisms (SNPs) were selected for genotyping in our asthma cohort (n = 1,439). Two common haplotypes in IL8 and three in IL8RA and IL8RB (defined as one block) were identified. Although none of the polymorphisms showed a significant association with risk of asthma, IL8RA-B ht2 showed a significant association with the peripheral blood eosinophil counts (%) among asthma patients, e.g., lower eosinophil levels among individuals with the homozygous IL8RA-B ht2 (3.55 ± 3.39%) than among other asthmatic patients (5.52 ± 5.55%; P corr = 0.018). Our findings suggest that polymorphisms and haplotypes in IL8RA and IL8RB might be among the genetic factors underlying production of peripheral blood eosinophil. © The Japan Society of Human Genetics and Springer-Verlag 2006. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | Polymorphisms in interleukin 8 and its receptors (IL8, IL8RA and IL8RB) and association of common IL8 receptor variants with peripheral blood eosinophil counts | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s10038-006-0021-5 | - |
dc.identifier.bibliographicCitation | Journal of Human Genetics, v.51, no.9, pp 781 - 787 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-33748674620 | - |
dc.citation.endPage | 787 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 781 | - |
dc.citation.title | Journal of Human Genetics | - |
dc.citation.volume | 51 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Asthma | - |
dc.subject.keywordAuthor | Eosinophil counts | - |
dc.subject.keywordAuthor | IL8 | - |
dc.subject.keywordAuthor | IL8RA | - |
dc.subject.keywordAuthor | IL8RB | - |
dc.subject.keywordAuthor | SNP | - |
dc.subject.keywordPlus | chemokine receptor CXCR1 | - |
dc.subject.keywordPlus | chemokine receptor CXCR2 | - |
dc.subject.keywordPlus | interleukin 8 | - |
dc.subject.keywordPlus | interleukin 8 receptor | - |
dc.subject.keywordPlus | mutant protein | - |
dc.subject.keywordPlus | adolescent | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | aged | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | asthma | - |
dc.subject.keywordPlus | child | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | DNA flanking region | - |
dc.subject.keywordPlus | eosinophil count | - |
dc.subject.keywordPlus | exon | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | genetic association | - |
dc.subject.keywordPlus | genetic polymorphism | - |
dc.subject.keywordPlus | genotype | - |
dc.subject.keywordPlus | haplotype | - |
dc.subject.keywordPlus | homozygosity | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | Korea | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | nucleotide sequence | - |
dc.subject.keywordPlus | promoter region | - |
dc.subject.keywordPlus | risk factor | - |
dc.subject.keywordPlus | sequence analysis | - |
dc.subject.keywordPlus | single nucleotide polymorphism | - |
dc.subject.keywordPlus | Adolescent | - |
dc.subject.keywordPlus | Adult | - |
dc.subject.keywordPlus | Aged | - |
dc.subject.keywordPlus | Aged, 80 and over | - |
dc.subject.keywordPlus | Asthma | - |
dc.subject.keywordPlus | Case-Control Studies | - |
dc.subject.keywordPlus | Child | - |
dc.subject.keywordPlus | Child, Preschool | - |
dc.subject.keywordPlus | Eosinophils | - |
dc.subject.keywordPlus | Female | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Interleukin-8 | - |
dc.subject.keywordPlus | Korea | - |
dc.subject.keywordPlus | Leukocyte Count | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Middle Aged | - |
dc.subject.keywordPlus | Polymorphism, Single Nucleotide | - |
dc.subject.keywordPlus | Receptors, Interleukin-8A | - |
dc.subject.keywordPlus | Receptors, Interleukin-8B | - |
dc.subject.keywordPlus | Risk Factors | - |
dc.subject.keywordPlus | Variation (Genetics) | - |
dc.description.journalRegisteredClass | scopus | - |
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