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Photo-immobilization of bone morphogenetic protein-2 using azidophenyl gelatin on a collagen sheet enhances osteogenesis in a rat calvarial defect model

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dc.contributor.authorHam, Dae Woong-
dc.contributor.authorJang, Eui Chan-
dc.contributor.authorSon, Tae Il-
dc.contributor.authorLee, Tae Jin-
dc.contributor.authorSong, Kwang-Sup-
dc.date.available2019-03-08T12:38:10Z-
dc.date.issued2016-08-
dc.identifier.issn1226-086X-
dc.identifier.issn1876-794X-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6623-
dc.description.abstractTwenty-eight rats were randomized into two groups: a control group comprising a collagen sheet with only cast BMP-2; and an experimental group comprising a collagen sheet with BMP-2 photo immobilized using azidophenyl gelatin. Micro-computed tomography analysis revealed that there was more regenerated bone in experimental group at both 4 and 8 weeks. Immunohistochemical analysis revealed that the positively expressed cellular ratio in RUNX2-stained cells were significantly higher in experimental group. These results demonstrate that BMP-2 photo-immobilized using Az-Gel on a collagen sheet shows promising bone regeneration, and the sheet is a good candidate of BMP-2 carrier. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.-
dc.format.extent8-
dc.language영어-
dc.language.isoENG-
dc.publisherELSEVIER SCIENCE INC-
dc.titlePhoto-immobilization of bone morphogenetic protein-2 using azidophenyl gelatin on a collagen sheet enhances osteogenesis in a rat calvarial defect model-
dc.typeArticle-
dc.identifier.doi10.1016/j.jiec.2016.06.021-
dc.identifier.bibliographicCitationJOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.40, pp 177 - 184-
dc.identifier.kciidART002134941-
dc.description.isOpenAccessN-
dc.identifier.wosid000381834800022-
dc.identifier.scopusid2-s2.0-84991013876-
dc.citation.endPage184-
dc.citation.startPage177-
dc.citation.titleJOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY-
dc.citation.volume40-
dc.type.docTypeReview-
dc.publisher.location미국-
dc.subject.keywordAuthorAzidophenyl gelatin-
dc.subject.keywordAuthorAz-Gel-
dc.subject.keywordAuthorBone morphogenetic protein-2 (BMP-2)-
dc.subject.keywordAuthorOsteogenesis-
dc.subject.keywordAuthorPhoto-immobilization-
dc.subject.keywordAuthorRat calvarial defect model-
dc.subject.keywordPlusCRITICAL SIZE DEFECT-
dc.subject.keywordPlusGRAFT SUBSTITUTE-
dc.subject.keywordPlusSEGMENTAL BONE-
dc.subject.keywordPlusDUAL DELIVERY-
dc.subject.keywordPlusGROWTH-FACTOR-
dc.subject.keywordPlusREGENERATION-
dc.subject.keywordPlusBMP-2-
dc.subject.keywordPlusOSTEOPONTIN-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusRELEASE-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryEngineering, Chemical-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
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