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Cited 15 time in webofscience Cited 17 time in scopus
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Wafer-scale high-resolution patterning of reduced graphene oxide films for detection of low concentration biomarkers in plasma

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dc.contributor.authorKim, Jinsik-
dc.contributor.authorChae, Myung-Sic-
dc.contributor.authorLee, Sung Min-
dc.contributor.authorJeong, Dahye-
dc.contributor.authorLee, Byung Chul-
dc.contributor.authorLee, Jeong Hoon-
dc.contributor.authorKim, YoungSoo-
dc.contributor.authorChang, Suk Tai-
dc.contributor.authorHwang, Kyo Seon-
dc.date.available2019-03-08T12:38:29Z-
dc.date.issued2016-08-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6642-
dc.description.abstractGiven that reduced graphene oxide (rGO)-based biosensors allow disposable and repeatable biomarker detection at the point of care, we developed a wafer-scale rGO patterning method with mass productivity, uniformity, and high resolution by conventional micro-electro-mechanical systems (MEMS) techniques. Various rGO patterns were demonstrated with dimensions ranging from 5 mu m up to several hundred mu m. Manufacture of these patterns was accomplished through the optimization of dry etching conditions. The axis-homogeneity and uniformity were also measured to verify the uniform patternability in 4-inch wafer with dry etching. Over 66.2% of uniform rGO patterns, which have deviation of resistance within range of +/- 10%, formed the entire wafer. We selected amyloid beta (A beta) peptides in the plasma of APP/PS1 transgenic mice as a study model and measured the peptide level by resistance changes of highly uniform rGO biosensor arrays. A beta is a pathological hallmark of Alzheimer's disease and its plasma concentration is in the pg mL(-1) range. The sensor detected the A beta peptides with ultra-high sensitivity; the LOD was at levels as low as 100 fg mL(-1). Our results provide biological evidences that this wafer-scale high-resolution patterning method can be used in rGO-based electrical diagnostic devices for detection of low-level protein biomarkers in biofluids.-
dc.language영어-
dc.language.isoENG-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleWafer-scale high-resolution patterning of reduced graphene oxide films for detection of low concentration biomarkers in plasma-
dc.typeArticle-
dc.identifier.doi10.1038/srep31276-
dc.identifier.bibliographicCitationScientific Reports, v.6-
dc.description.isOpenAccessY-
dc.identifier.wosid000381109400001-
dc.identifier.scopusid2-s2.0-84981320868-
dc.citation.titleScientific Reports-
dc.citation.volume6-
dc.type.docTypeArticle-
dc.publisher.location영국-
dc.subject.keywordPlusTHIN-FILMS-
dc.subject.keywordPlusELECTRODES-
dc.subject.keywordPlusBIOSENSOR-
dc.subject.keywordPlusTRANSPARENT-
dc.subject.keywordPlusPROTEIN-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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