Wafer-scale high-resolution patterning of reduced graphene oxide films for detection of low concentration biomarkers in plasma
DC Field | Value | Language |
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dc.contributor.author | Kim, Jinsik | - |
dc.contributor.author | Chae, Myung-Sic | - |
dc.contributor.author | Lee, Sung Min | - |
dc.contributor.author | Jeong, Dahye | - |
dc.contributor.author | Lee, Byung Chul | - |
dc.contributor.author | Lee, Jeong Hoon | - |
dc.contributor.author | Kim, YoungSoo | - |
dc.contributor.author | Chang, Suk Tai | - |
dc.contributor.author | Hwang, Kyo Seon | - |
dc.date.available | 2019-03-08T12:38:29Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6642 | - |
dc.description.abstract | Given that reduced graphene oxide (rGO)-based biosensors allow disposable and repeatable biomarker detection at the point of care, we developed a wafer-scale rGO patterning method with mass productivity, uniformity, and high resolution by conventional micro-electro-mechanical systems (MEMS) techniques. Various rGO patterns were demonstrated with dimensions ranging from 5 mu m up to several hundred mu m. Manufacture of these patterns was accomplished through the optimization of dry etching conditions. The axis-homogeneity and uniformity were also measured to verify the uniform patternability in 4-inch wafer with dry etching. Over 66.2% of uniform rGO patterns, which have deviation of resistance within range of +/- 10%, formed the entire wafer. We selected amyloid beta (A beta) peptides in the plasma of APP/PS1 transgenic mice as a study model and measured the peptide level by resistance changes of highly uniform rGO biosensor arrays. A beta is a pathological hallmark of Alzheimer's disease and its plasma concentration is in the pg mL(-1) range. The sensor detected the A beta peptides with ultra-high sensitivity; the LOD was at levels as low as 100 fg mL(-1). Our results provide biological evidences that this wafer-scale high-resolution patterning method can be used in rGO-based electrical diagnostic devices for detection of low-level protein biomarkers in biofluids. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Wafer-scale high-resolution patterning of reduced graphene oxide films for detection of low concentration biomarkers in plasma | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/srep31276 | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.6 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000381109400001 | - |
dc.identifier.scopusid | 2-s2.0-84981320868 | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 6 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | THIN-FILMS | - |
dc.subject.keywordPlus | ELECTRODES | - |
dc.subject.keywordPlus | BIOSENSOR | - |
dc.subject.keywordPlus | TRANSPARENT | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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