Development of a new tri-block copolymer with a functional end and its feasibility for treatment of metastatic breast cancer
DC Field | Value | Language |
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dc.contributor.author | Song, Ho-Taek | - |
dc.contributor.author | Hoang, Ngoc Ha | - |
dc.contributor.author | Yun, Jeong Min | - |
dc.contributor.author | Park, Young Jin | - |
dc.contributor.author | Song, Eun Hye | - |
dc.contributor.author | Lee, Eun Seong | - |
dc.contributor.author | Youn, Yu Seok | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.date.available | 2019-03-08T12:38:40Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.issn | 1873-4367 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6651 | - |
dc.description.abstract | We have developed nanomedicine vehicle based on a biocompatible tri-block copolymer, poly(ethylene glycol)-block-poly(lactic acid)-block-poly(ethylene glycol) (PEG-PLA-PEG) by simple approach without toxic linker to escalate therapeutic efficacy of anticancer agent by enhanced targeting to metastasized breast cancers. The synthesized ABA type copolymer had a low polydispersity index and formed small, highly stable spherical micelles. Furthermore, a functional group at the end site of the copolymer can be decorated with imaging agents and targeting moieties. The doxorubicin loaded micelles (DLM) showed higher drug-loading capacity, faster drug release, and better cell toxicity compared to those using di-block copolymers. DLM efficiently delivered to the metastatic breast cancers in brain and bone and suppressed growing of metastasis. In demonstration of treating metastasized animal model, we present a tri-block copolymer as. a potential nanomedicine vehicle to efficiently deliver anticancer drug and to effectively treat metastatic breast cancer. Crown Copyright (C) 2016 Published by Elsevier B.V. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Development of a new tri-block copolymer with a functional end and its feasibility for treatment of metastatic breast cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.colsurfb.2016.04.002 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.144, pp 73 - 80 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000377837200009 | - |
dc.identifier.scopusid | 2-s2.0-84962746646 | - |
dc.citation.endPage | 80 | - |
dc.citation.startPage | 73 | - |
dc.citation.title | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.volume | 144 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Metastasis | - |
dc.subject.keywordAuthor | Nanomedicine | - |
dc.subject.keywordAuthor | Tri-block copolymer | - |
dc.subject.keywordAuthor | Animal imaging | - |
dc.subject.keywordAuthor | Biocompatibility | - |
dc.subject.keywordPlus | POLY(ASPARTIC ACID-GRAFT-IMIDAZOLE)-BLOCK-POLY(ETHYLENE GLYCOL) | - |
dc.subject.keywordPlus | SENSITIVE POLYMERIC MICELLES | - |
dc.subject.keywordPlus | PEG TRIBLOCK COPOLYMERS | - |
dc.subject.keywordPlus | DRUG-DELIVERY SYSTEMS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | NANOCARRIERS | - |
dc.subject.keywordPlus | SONICATION | - |
dc.subject.keywordPlus | WATER | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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