자궁내막의 정상, 증식증 및 선암종에서의 Bcl-2 발현

Abstract

To evaluate the expression of Bcl-2, known as a candidate apoptosis suppressor gene, of normal and pathologic endometrial lesion, immunohistochemical studies were carried out by using avidin-biotin complex immunoperoxidase technique in paraffin embedded tissue sections from 50 cases. This studies consisted of 6 cases of early proliferative endometrium, 9 cases of late proliferative endometrium, 5 cases of early secretory endometrium, 10 cases of late secretory endometrium, 10 cases of cystic endometrial hyperplasia and 10 cases of endometrile adenocarcinoma including 3 cases of well differentiated type, 2 cases of moderate differentiated type, 3 cases of poorly differentiated type and 2 cases of adenosquamous carcinoma. The results were as follows; 1. Bcl-2 expression of proliferative endometrium was gradually increased from early proliferative phase to late proliferative phase. 2. Bcl-2 expression ofsecretory endoemtrium was loser than that of proliferative endometrium. 3. Bcl-2 expression of cystic endometrial hyperplasia was more heterogenous than that of proliferative endometrium. 4. Bcl-2 expression of endoemtrial adenocarcinoma depended upon the differentiation of cancer cell. 5. Therefore, authors suggested that Bcl-2 expression was associated with endometrial proliferation and carcinogenesis.