디펩타이드의 B16 악성흑색종세포에서 멜라닌 생성억제작용
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남희승 | - |
dc.contributor.author | 김은현 | - |
dc.contributor.author | 김수연 | - |
dc.contributor.author | 이현이 | - |
dc.contributor.author | 홍지연 | - |
dc.contributor.author | 이재국 | - |
dc.contributor.author | 조성태 | - |
dc.contributor.author | 조양환 | - |
dc.contributor.author | 윤혜영 | - |
dc.contributor.author | 백광진 | - |
dc.contributor.author | 권년수 | - |
dc.contributor.author | 민영실 | - |
dc.contributor.author | 박경찬 | - |
dc.contributor.author | 김동석 | - |
dc.date.accessioned | 2023-06-12T09:40:41Z | - |
dc.date.available | 2023-06-12T09:40:41Z | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 1226-2587 | - |
dc.identifier.issn | 2288-9507 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66760 | - |
dc.description.abstract | 본 연구에서는 B16 악성흑색종 세포에서 디펩타이드(dipeptide)의 멜라닌생성 저해 효과를 연구하였다. 실험결과 WV (트립토판-발린), WM (트립토판-메치오닌), CQ (시스테인-글루타민)는 멜라닌 생성을 농도 의존적으로 감소시켰다. 그러나 디펩타이드는 멜라닌 생합성과정의 속도 조절 단계 효소인 타이로시네이즈(tyrosinase)의 활성을 직접 감소시키지는 않았다. 따라서 타이로시네이즈의 발현양상을 조사하였고, 실험 결과 α-MSH가 유도한 타이로시네이즈발현이 WV, WM, 그리고 CQ에 의해 억제되었다. 그러므로 WV, WM, 그리고 CQ가 타이로시네이즈의 억제성 조절(down-regulation)을 통해 멜라닌 생성을 감소시킨다고 제안될 수 있다. | - |
dc.description.abstract | In the present study, we investigated the effects of dipeptides on melanogenesis in B16 melanoma cells. It was found that WV (Trp+Val), WM (Trp+Met), and CQ (Cys+Gln) decreased melanin production dosedependently. However, dipeptides did not directly inhibit tyrosinase activity, the rate-limiting melanogenic enzyme. Therefore, we further investigated the expression of tyrosinase. Our results showed that α-MSH-induced tyrosinase expression was down-regulated by WV, WM, and CQ. Thus, we propose that WV, WM, and CQ show hypopigmentary activity through tyrosinase down-regulation. | - |
dc.format.extent | 7 | - |
dc.publisher | 대한화장품학회 | - |
dc.title | 디펩타이드의 B16 악성흑색종세포에서 멜라닌 생성억제작용 | - |
dc.title.alternative | Hypopigmentary Effects of Dipeptides in B16 Melanoma Cells | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 대한화장품학회지, v.38, no.1, pp 67 - 73 | - |
dc.identifier.kciid | ART001651608 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 73 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 67 | - |
dc.citation.title | 대한화장품학회지 | - |
dc.citation.volume | 38 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | α-MSH | - |
dc.subject.keywordAuthor | dipeptides | - |
dc.subject.keywordAuthor | melanogenesis | - |
dc.subject.keywordAuthor | tyrosinase | - |
dc.subject.keywordAuthor | melanin | - |
dc.description.journalRegisteredClass | kciCandi | - |
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