스테로이드가 신생 흰쥐 해마형성체 신경원의 퇴행에 미치는 영향

Abstract

The influences of adrenal corticosteroid on the development and regression of the neurons of hippocampal and dentate were examined in the steroid overloaded neonatal rats. The results obtained were as follows. The regression occurred naturally in numerous dentate granule cells and hippocampal pyramidal cells, which was the apoptotic process. The apoptotic granule cells in dentate gyrus decreased in number with steroid overload, and this change was more prominent at 6 days than at 4 days. The decrease in the number of apoptotic neurons by steroid overload occurred only in the upper limb of dentate gyrus at 6 days. The gradient of regression in dentate gyrus had no relation with the gradient of neurogenesis, and the regression of hippocampal pyramidal cells decreased in the gyrus but not in CA regions. In conclusion, the cell death occurred in neurons of hippocampal formation, which was the process of apoptosis. The adrenal corticosteroid seemed to be influential significantly on the development and regression of the neurons.