Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | KIM, Dong-Seok | - |
dc.contributor.author | KIM, So-Young | - |
dc.contributor.author | PARK, Seo-Hyoung | - |
dc.contributor.author | CHOI, Yeong-Gon | - |
dc.contributor.author | KWON, a Sun-Bang | - |
dc.contributor.author | KIM, Myo-Kyoung | - |
dc.contributor.author | NA, Jung-Im | - |
dc.contributor.author | YOUN, Sang-Woong | - |
dc.contributor.author | PARK, Kyoung-Chan | - |
dc.date.accessioned | 2023-06-16T05:42:46Z | - |
dc.date.available | 2023-06-16T05:42:46Z | - |
dc.date.issued | 2005-12 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.issn | 1347-5215 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66849 | - |
dc.description.abstract | In this study, we investigated the effects of 4-n-butylresorcinol on melanogenesis in a spontaneously immortalized mouse melanocyte cell line, Mel-Ab. Our results show that 4-n-butylresorcinol significantly inhibits melanin synthesis in a concentration-dependent manner. In addition, it was also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. Several reports have indicated that the activation of extracellular signal-regulated kinase (ERK) or of Akt reduces melanin synthesis via microphthalmia-associated transcription factor (MITF) down-regulation. Accordingly, we examined the effects of 4-n-butylresorcinol on the ERK and Akt signaling pathways. 4-n-Butylresorcinol did not induce ERK, Akt activation, or MITF degradation, and had no effect on cAMP response element binding protein (CREB) phosphorylation, which stimulates MITF expression. In contrast, 4-n-butylresorcinol strongly reduced tyrosinase activity in a cell-free system. Moreover, 4-n-butylresorcinol showed an additive effect in combination with hinokitiol, which reduces MITF expression. These results show that the hypopigmentary effect of 4-n-butylresorcinol results from its direct inhibition of tyrosinase. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.title | Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1248/bpb.28.2216 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.28, no.12, pp 2216 - 2219 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000234096100008 | - |
dc.identifier.scopusid | 2-s2.0-28744438577 | - |
dc.citation.endPage | 2219 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2216 | - |
dc.citation.title | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 28 | - |
dc.type.docType | Article | - |
dc.publisher.location | 일본 | - |
dc.subject.keywordAuthor | 4-n-butylresorcinol | - |
dc.subject.keywordAuthor | melanogenesis | - |
dc.subject.keywordAuthor | tyrosinase | - |
dc.subject.keywordAuthor | microphthalmia-associated transcription factor (MITF) | - |
dc.subject.keywordPlus | MICROPHTHALMIA GENE-PRODUCT | - |
dc.subject.keywordPlus | WAARDENBURG-SYNDROME | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | CELL DIFFERENTIATION | - |
dc.subject.keywordPlus | FUNCTIONAL-ANALYSIS | - |
dc.subject.keywordPlus | ERK ACTIVATION | - |
dc.subject.keywordPlus | CYCLIC-AMP | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | MITF | - |
dc.subject.keywordPlus | MELANOGENESIS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.