Growth related secretion and production of GM-CSF by epithelial cell line
DC Field | Value | Language |
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dc.contributor.author | Park, Kyoung Chan | - |
dc.contributor.author | Kim, Dong Seok | - |
dc.contributor.author | Kim, Hye Jin | - |
dc.contributor.author | Seo, Koo Il | - |
dc.contributor.author | Kim, Kyu Han | - |
dc.contributor.author | Chung, Jin Ho | - |
dc.contributor.author | Eun, Hee Chul | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.date.accessioned | 2023-06-16T05:44:40Z | - |
dc.date.available | 2023-06-16T05:44:40Z | - |
dc.date.issued | 2001-01 | - |
dc.identifier.issn | 0923-1811 | - |
dc.identifier.issn | 1873-569X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66869 | - |
dc.description.abstract | Granulocyte-macrophage colony stimulating factor (GM-CSF) is a growth factor that supports the clonal development of normal granulocyte-macrophage progenitors. Especially in the skin, GM-CSF from keratinocytes may be a critical factor in the melanogenesis of the skin. In addition, GM-CSF is thought to play an important role in impaired wound healing. However, little is known regarding the synthesis and secretion of GM-CSF by keratinocytes of the skill. This investigation evaluated the effects of cell density on the production of GM-CSF by keratinocytes and the changes in the cell cycle. Interestingly, GM-CSF protein secretions and mRNA expressions were highly elevated in sub-confluent HaCat cells, and decreased in confluent state. In particular, GM-CSF production decreased in a density-dependent manner. We also found that the percentage of cells in the S phase of the cell cycle decreased markedly from 50 to 10%, when HaCat cells reached a confluent state. These results showed that GM-CSF synthesis and secretion by HaCat cells increases when cells are rapidly proliferating such as in the wound healing process. Thus, it might be said that GM-CSF produced by proliferating keratinocytes possibly contributes to wound healing and melanogenesis at the site of injury. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI IRELAND LTD | - |
dc.title | Growth related secretion and production of GM-CSF by epithelial cell line | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/S0923-1811(00)00111-0 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DERMATOLOGICAL SCIENCE, v.25, no.1, pp 53 - 58 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000166456000007 | - |
dc.identifier.scopusid | 2-s2.0-0035189706 | - |
dc.citation.endPage | 58 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 53 | - |
dc.citation.title | JOURNAL OF DERMATOLOGICAL SCIENCE | - |
dc.citation.volume | 25 | - |
dc.type.docType | Article | - |
dc.publisher.location | 아일랜드 | - |
dc.subject.keywordAuthor | granulocyte-macrophage colony stimulating factor | - |
dc.subject.keywordAuthor | wound healing | - |
dc.subject.keywordAuthor | melanogenesis | - |
dc.subject.keywordAuthor | keratinocytes | - |
dc.subject.keywordPlus | COLONY-STIMULATING FACTOR | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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