Transforming growth factor-β1 decreases melanin synthesis via delayed extracellular signal-regulated kinase activation
DC Field | Value | Language |
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dc.contributor.author | Kim, Dong-Seok | - |
dc.contributor.author | Park, Seo-Hyoung | - |
dc.contributor.author | Park, Kyoung-Chan | - |
dc.date.accessioned | 2023-06-16T06:41:36Z | - |
dc.date.available | 2023-06-16T06:41:36Z | - |
dc.date.issued | 2004-08 | - |
dc.identifier.issn | 1357-2725 | - |
dc.identifier.issn | 1878-5875 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66876 | - |
dc.description.abstract | Transforming growth factor-beta1 (TGF-beta1) plays a pivotal role in cell proliferation, differentiation, and apoptosis. In this study, we investigated the effects of TGF-beta1 on melanogenesis using a spontaneously immortalized mouse melanocyte cell line, Mel-Ab. Our results show that TGF-beta1 significantly inhibits melanin synthesis in a concentration-dependent manner and that it reduces the activity of tyrosinase, the rate-limiting melanogenic enzyme. We also found that TGF-beta1 reduces microphthalmia-associated transcription factor (MITF) promoter activity and decreased MITF, tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2 protein production. In addition, TGF-beta1 was found to induce a delay in the activation of extracellular signal-regulated kinase (ERK) at 6 h, whereas many growth factors activate ERK transiently in minutes. Moreover, the specific ERK pathway inhibitor, PD98059 blocked the hypopigmenting effects induced by TGF-beta1. PD98059 was also found to abrogate the TGF-beta1-mediated down-regulation of MITF, tyrosinase, TRP-1, and TRP-2 production. These results suggest that the ERK pathway may be involved in the melanogenic signaling cascade, and that delayed ERK activation by TGF-beta1 contributes to reduced melanin synthesis via MITF down-regulation. (C) 2003 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Transforming growth factor-β1 decreases melanin synthesis via delayed extracellular signal-regulated kinase activation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biocel.2003.10.023 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, v.36, no.8, pp 1482 - 1491 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000222204400014 | - |
dc.identifier.scopusid | 2-s2.0-2442513449 | - |
dc.citation.endPage | 1491 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1482 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | - |
dc.citation.volume | 36 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | transforming growth factor-beta 1 | - |
dc.subject.keywordAuthor | melanogenesis | - |
dc.subject.keywordAuthor | MITF | - |
dc.subject.keywordAuthor | tyrosinase | - |
dc.subject.keywordAuthor | EPK | - |
dc.subject.keywordPlus | MICROPHTHALMIA GENE-PRODUCT | - |
dc.subject.keywordPlus | TYROSINASE-RELATED PROTEIN-1 | - |
dc.subject.keywordPlus | NERVE GROWTH-FACTOR | - |
dc.subject.keywordPlus | MAP KINASE | - |
dc.subject.keywordPlus | WAARDENBURG-SYNDROME | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | CELL DIFFERENTIATION | - |
dc.subject.keywordPlus | AMELANOTIC MELANOMA | - |
dc.subject.keywordPlus | FUNCTIONAL-ANALYSIS | - |
dc.subject.keywordPlus | ERK ACTIVATION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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