Effects of Ascorbic Acid on Keratinocyte and Epidermalization of Skin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Kyoung-Chan | - |
dc.contributor.author | Choi, Hye-Ryung | - |
dc.contributor.author | Cho, Hyun-Joo | - |
dc.contributor.author | Kim, Soon-Kyum | - |
dc.contributor.author | Kwon, Sun-Bang | - |
dc.contributor.author | Kim, Dong-Seok | - |
dc.contributor.author | Cho, Young-Joon | - |
dc.contributor.author | Yoon, Sang-Woong | - |
dc.date.accessioned | 2023-06-16T07:31:17Z | - |
dc.date.available | 2023-06-16T07:31:17Z | - |
dc.date.issued | 2004-04 | - |
dc.identifier.issn | 1013-9087 | - |
dc.identifier.issn | 2005-3894 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66878 | - |
dc.description.abstract | Background: There are different models of skin substitutes, but no skin substitutes have the characteristics of native skin. It was reported that the incubation of skin substitutes in medium containing ascorbic acid extends cellular viability and promotes formation of an epidermal barrier in vitro. Objective: The purpose of this study is to observe the effects of ascorbic acid on the proliferation of keratinocytes and on the reconstruction of epidermis. Materials and Methods: Normal human keratinocytes and fibroblasts were isolated and used for culturing living skin equivalent (LSE). Results: When ascorbic acid was added, the expression of p63 and a6 integrin was definitely increased compared to control models. In addition, ascorbic acid increased the proliferation of normal human keratinocytes at a dose dependent manner. Especially, ascorbic acid induced the phosphorylation of ERK and up-regulation of EGF-R Conclusion: Results suggest that ascorbic acid is essential in the control of keratinocyte proliferation and basement membrane formation. Ascorbic acid-related keratinocytes proliferation is seemed to be mediated by ERK phosphorylation and EGF-R up-regulation. | - |
dc.format.extent | 7 | - |
dc.publisher | 대한피부과학회 | - |
dc.title | Effects of Ascorbic Acid on Keratinocyte and Epidermalization of Skin | - |
dc.type | Article | - |
dc.identifier.doi | 10.5021/ad.2004.16.2.45 | - |
dc.identifier.bibliographicCitation | Annals of Dermatology, v.16, no.2, pp 45 - 51 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 51 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 45 | - |
dc.citation.title | Annals of Dermatology | - |
dc.citation.volume | 16 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Ascorbic acid | - |
dc.subject.keywordAuthor | Keratinocytes | - |
dc.subject.keywordAuthor | LSE | - |
dc.subject.keywordAuthor | living skin equivalent | - |
dc.description.journalRegisteredClass | domestic | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.