Effects of Dexamethasone on Endothelin-1(ET-1) Production by Keratinocytes
DC Field | Value | Language |
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dc.contributor.author | Lee, Il Whan | - |
dc.contributor.author | Lee, Seung Chul | - |
dc.contributor.author | Kim, Dong Seok | - |
dc.contributor.author | Kim, Hye Jin | - |
dc.contributor.author | Park, Kyoung Chan | - |
dc.date.accessioned | 2023-06-16T07:31:35Z | - |
dc.date.available | 2023-06-16T07:31:35Z | - |
dc.date.issued | 2001-07 | - |
dc.identifier.issn | 1013-9087 | - |
dc.identifier.issn | 2005-3894 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66881 | - |
dc.description.abstract | Epidermal keratinocytes are important sources of a wide variety of cytokines that include the endothelin-1 (ET-1). Glucocorticoids have been shown to inhibit the production of several cytokines. However, their effect on ET-1 synthesis by keratinocytes is still unknown. It has been reported that ultraviolet B (UVB) irradiation stimulates both the synthesis and release of ET-1 and it was observed that ET-1 secretion by HaCat cells increased with increasing UVB exposure. In this study, the effects of glucocorticoid on ET-1 production were evaluated using cultured HaCat keratinocytes. The results showed that dexamethasone suppressed basal re-lease of ET-1. In addition, it strongly inhibited the UVB-mediated augmentation of ET-1 production. Furthermore, lincomycin slightly enhanced the inhibitory effect of dexamethasone on ET-1 synthesis. | - |
dc.format.extent | 5 | - |
dc.publisher | 대한피부과학회 | - |
dc.title | Effects of Dexamethasone on Endothelin-1(ET-1) Production by Keratinocytes | - |
dc.type | Article | - |
dc.identifier.doi | 10.5021/ad.2001.13.3.148 | - |
dc.identifier.bibliographicCitation | Annals of Dermatology, v.13, no.3, pp 148 - 152 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 152 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 148 | - |
dc.citation.title | Annals of Dermatology | - |
dc.citation.volume | 13 | - |
dc.publisher.location | 대한민국 | - |
dc.description.journalRegisteredClass | domestic | - |
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