Gh: A GTP-Binding Protein with Transglutaminase Activity and Receptor Signaling Function
DC Field | Value | Language |
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dc.contributor.author | Nakaoka, Hideaki | - |
dc.contributor.author | Perez, Dianne M. | - |
dc.contributor.author | Baek, Kwang Jin | - |
dc.contributor.author | Das, Tanya | - |
dc.contributor.author | Husain, Ahsan | - |
dc.contributor.author | Misono, Kunio | - |
dc.contributor.author | Im, Mie-Jae | - |
dc.contributor.author | Graham, Robert M. | - |
dc.date.accessioned | 2023-06-22T05:42:42Z | - |
dc.date.available | 2023-06-22T05:42:42Z | - |
dc.date.issued | 1994-06 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.issn | 1095-9203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66989 | - |
dc.description.abstract | The alpha(1)-adrenergic receptors activate a phospholipase C enzyme by coupling to members of the large molecular size (approximately 74 to 80 kilodaltons) G alpha(h) family of guanosine triphosphate (GTP)-binding proteins. Rat liver G alpha(h) is now shown to be a tissue transglutaminase type II (TGase II). The transglutaminase activity of rat liver TGase II expressed in COS-1 cells was inhibited by the nonhydrolyzable GTP analog guanosine 5'-O-(3-thiotriphosphate) or by alpha(1)-adrenergic receptor activation. Rat liver TGase II also mediated alpha(1)-adrenergic receptor stimulation of phospholipase C activity. Thus, G alpha(h) represents a new class of GTP-binding proteins that participate in receptor signaling and may be a component of a complex regulatory network in which receptor-stimulated GTP binding switches the function of G alpha(h) from transglutamination to receptor signaling. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Gh: A GTP-Binding Protein with Transglutaminase Activity and Receptor Signaling Function | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/science.7911253 | - |
dc.identifier.bibliographicCitation | SCIENCE, v.264, no.5165, pp 1593 - 1596 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | A1994NQ28500037 | - |
dc.identifier.scopusid | 2-s2.0-0028176166 | - |
dc.citation.endPage | 1596 | - |
dc.citation.number | 5165 | - |
dc.citation.startPage | 1593 | - |
dc.citation.title | SCIENCE | - |
dc.citation.volume | 264 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | PIG LIVER TRANSGLUTAMINASE | - |
dc.subject.keywordPlus | PHOSPHOLIPASE-C | - |
dc.subject.keywordPlus | ALPHA-SUBUNITS | - |
dc.subject.keywordPlus | ALPHA-1-ADRENERGIC RECEPTOR | - |
dc.subject.keywordPlus | CDNA CLONES | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | RECONSTITUTION | - |
dc.subject.keywordPlus | PURIFICATION | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | ALPHA(1)-ADRENOCEPTOR | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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