Effect of statins on experimental postoperative adhesion: a systematic review and meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Geun Joo | - |
dc.contributor.author | Park, Hee Kyung | - |
dc.contributor.author | Kim, Dong Su | - |
dc.contributor.author | Lee, Donghyun | - |
dc.contributor.author | Kang, Hyun | - |
dc.date.available | 2019-01-22T12:34:32Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/669 | - |
dc.description.abstract | Adhesion is a significant concern after surgery. Many researchers studied the anti-adhesive effect of statin, of which results were inconsistent. Thus, we purposed to perform a systematic review and meta-analysis to evaluate the effect of statins on postoperative adhesion in an experimental study. A comprehensive search was conducted using MEDLINE, EMBASE, and Google Scholar to identify animal studies that investigated the postoperative anti-adhesive effect of statins applied at the surgical area. Primary outcome measure was gross adhesion score. Secondary outcomes included microscopic adhesion score and tissue plasminogen activator (t-PA) activity. Totally, 298 rats from 9 animal studies (172 rats received statin therapy and 126 rats received placebo or no treatment) were included in the final analysis. The combined results showed that gross and microscopic adhesion scores were significantly lower in the statin group in comparison to the control group (standardized mean difference [SMD] = 1.65, 95% confidence interval [CI]: 1.02 to 2.28, P-chi(2) < 0.001, I-2 = 77.9%; SMD = 1.90, 95% CI: 1.10 to 2.79, P-chi(2) < 0.001, I-2 = 84.5%, respectively). However, there was no evidence of a difference in t-PA activity (SMD = -3.43, 95% CI: -7.95 to 1.09, P-chi(2) < 0.001, I-2 = 95.5%). In conclusion, statins were effective in preventing postoperative adhesion, as assessed based on gross and microscopic adhesion scores in rats. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Effect of statins on experimental postoperative adhesion: a systematic review and meta-analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-018-33145-z | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.8, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000446339400038 | - |
dc.identifier.scopusid | 2-s2.0-85054329713 | - |
dc.citation.number | 1 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | COA REDUCTASE INHIBITORS | - |
dc.subject.keywordPlus | INCREASES FIBRINOLYTIC-ACTIVITY | - |
dc.subject.keywordPlus | PERITONEAL MESOTHELIAL CELLS | - |
dc.subject.keywordPlus | SMALL-BOWEL OBSTRUCTION | - |
dc.subject.keywordPlus | CLINICAL-SIGNIFICANCE | - |
dc.subject.keywordPlus | ABDOMINAL ADHESIONS | - |
dc.subject.keywordPlus | TOPICAL APPLICATION | - |
dc.subject.keywordPlus | TISSUE FACTOR | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | SIMVASTATIN | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.