Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sung, Hyun Jea | - |
dc.contributor.author | Choi,Sun Mi | - |
dc.contributor.author | Yoon, Yoosik | - |
dc.contributor.author | An, Kyu Suk | - |
dc.date.accessioned | 2023-07-06T02:40:46Z | - |
dc.date.available | 2023-07-06T02:40:46Z | - |
dc.date.issued | 1999-12 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.issn | 2092-6413 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67069 | - |
dc.description.abstract | Tanshinone II-A is a derivative of phenanthrenequinone isolated from Salvia miltiorrhiza BUNGE, a traditional herbal medicine that is known to induce antiinflammatory, anti-oxidative and cytotoxic activity. We have examined cellular effects of Tanshione II-A on HL60 human promyelocytic leukemic cells and K562 human erythroleukemic cells. Tanshione II-A induced a dose- and time-dependent DNA fragmentation into the multiples of 180 bp and specific proteolytic cleavage of poly(ADP-ribose) polymerase in both cell lines. PI-staining and flow cytometry analysis of K562 cells following Tanshione II-A treatment showed an increase of the cells possessing hypodiploid DNA indicative of apoptotic state of cells. Caspase-3 activity was significantly increased during Tanshinone II-A treatment of both HL60 and K562 cells, whereas caspase-1 activity was not changed. These results suggest that Tanshione II-A induced HL60 and K562 cellular apoptosis that may be associated with the selective members of caspase family. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/emm.1999.28 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.31, no.4, pp 174 - 178 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000084580000002 | - |
dc.identifier.scopusid | 2-s2.0-0033621456 | - |
dc.citation.endPage | 178 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 174 | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 31 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | caspase-3 | - |
dc.subject.keywordAuthor | leukemia | - |
dc.subject.keywordAuthor | Salvia miltiorrhiza BUNGE | - |
dc.subject.keywordAuthor | tanshinone II-A | - |
dc.subject.keywordPlus | INTERNUCLEOSOMAL DNA FRAGMENTATION | - |
dc.subject.keywordPlus | PROTEASE | - |
dc.subject.keywordPlus | CANCER | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kciCandi | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.