The finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kil Soo | - |
dc.contributor.author | Cho, Dae-Yeon | - |
dc.contributor.author | Kim, Young Joo | - |
dc.contributor.author | Choi, Sun Mi | - |
dc.contributor.author | Kim, Jong Yeol | - |
dc.contributor.author | Shin, Seung Uoo | - |
dc.contributor.author | Yoon, Yoo Sik | - |
dc.date.accessioned | 2023-07-06T03:40:55Z | - |
dc.date.available | 2023-07-06T03:40:55Z | - |
dc.date.issued | 2005-06 | - |
dc.identifier.issn | 0925-4439 | - |
dc.identifier.issn | 1879-260X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67074 | - |
dc.description.abstract | A-1766G polymorphism, for the first time, has been found in the sequencing of pooled and individual genomic DNA of Korean subjects at the 5' flanking region of the UCP-1 gene. The effects of new polymorphism on body fat were elucidated among 387 Korean female subjects. It was shown that the genotypes AA, AG, and GG were consisted of 57.4%, 37.7%, and 4.9%, respectively, which was in agreement with Hardy-Weinberg equilibrium (P=0.327). The frequency of major A allele was 0.762 and that of minor G allele was 0.238. It is found that the waist-hip ratio (WHR) (P=0.008), body fat mass (P=0.023), and percent body fat (P=0.014) are significantly higher in the AG/GG type compared to the AA type. When the subjects were analyzed using computerized tomography, there were significant increases in the AG/GG type compared to the AA type in the abdominal subcutaneous fat (P=0.015) and the abdominal visceral fat (P=0.013), respectively. A1766G is approximately 2 kb downstream from the well-known A-3826G polymorphism, and no linkage between them was found (D'-0.929, R-2=0.283). Three haplotypes (frequency > 0.05) were examined from two polymorphisms and Studied for their physiological effects. It was found that haplotype [GG] was significantly associated with increased body fat, while haplotype [GA] was associated with decreased body fat. (c) 2004 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | The finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbadis.2004.11.026 | - |
dc.identifier.bibliographicCitation | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v.1741, no.1-2, pp 149 - 155 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000230255600018 | - |
dc.identifier.scopusid | 2-s2.0-20444498707 | - |
dc.citation.endPage | 155 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 149 | - |
dc.citation.title | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | - |
dc.citation.volume | 1741 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | UCP-1 | - |
dc.subject.keywordAuthor | A-1766G | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | SNP | - |
dc.subject.keywordAuthor | haplotype | - |
dc.subject.keywordAuthor | fat | - |
dc.subject.keywordPlus | BROWN ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | UNCOUPLING PROTEIN UCP | - |
dc.subject.keywordPlus | HAPLOTYPE RECONSTRUCTION | - |
dc.subject.keywordPlus | DNA POLYMORPHISM | - |
dc.subject.keywordPlus | OBESE | - |
dc.subject.keywordPlus | HUMANS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | VARIANT | - |
dc.subject.keywordPlus | WOMEN | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.