The effects of uncoupling protein 3 haplotypes on obesity phenotypes and very low-energy diet-induced changes among overweight Korean female subjects
DC Field | Value | Language |
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dc.contributor.author | Cha, Min Ho | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Kim, Kil Soo | - |
dc.contributor.author | Lee, Bong Hee | - |
dc.contributor.author | Yoon, Yoosik | - |
dc.date.accessioned | 2023-07-06T05:41:15Z | - |
dc.date.available | 2023-07-06T05:41:15Z | - |
dc.date.issued | 2006-05 | - |
dc.identifier.issn | 0026-0495 | - |
dc.identifier.issn | 1532-8600 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67080 | - |
dc.description.abstract | Responses to energy restriction tend to vary within the population because of genetic differences. In this study, we have genotyped 6 uncoupling protein 3 (UCP-3) polymorphisms (-55C/T, Int2-143G/C, Tyr99Tyr, Int3-47G/A, Int4-498C/T, and Tyr210Tyr) among 214 overweight Korean female subjects recruited from an obesity clinic. Three major haplotypes, identified with frequencies in excess of 0.04, were constructed from 6 single nucleotide polymorphisms. Association studies were then undertaken, involving the measurement of anthropometric characteristics and body composition both before and after I month of a energy-restriction regimen. At baseline, haplotype 1 (ht 1) [CGTACC] was associated with elevated anthropometric characteristics, including body weight, waist-hip ratio, and body mass index, as well as body components, including body fat mass and body fat-free mass. After the completion of the 1-month weight control program, which involved a very low-energy (2900 kJ/d) diet, we analyzed the outcomes according to the UCP-3 genetic polymorph isms. Among the 3 principal haplotypes, ht1 [CGTACC] was significantly associated with an increased reduction in body weight, in the codominant (P = .022), dominant (P = .016), and recessive (P = .041) models. Body mass index reduction was associated with the ht1 haplotype in a similar fashion. Among the body components, changes in body fat mass were significantly associated with ht1 [CGTACC] (P = .028), but changes in body fat-free mass were not significantly associated with the UCP-3 polymorphism. (c) 2006 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.title | The effects of uncoupling protein 3 haplotypes on obesity phenotypes and very low-energy diet-induced changes among overweight Korean female subjects | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.metabol.2005.11.012 | - |
dc.identifier.bibliographicCitation | METABOLISM-CLINICAL AND EXPERIMENTAL, v.55, no.5, pp 578 - 586 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000237400700004 | - |
dc.identifier.scopusid | 2-s2.0-33646487792 | - |
dc.citation.endPage | 586 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 578 | - |
dc.citation.title | METABOLISM-CLINICAL AND EXPERIMENTAL | - |
dc.citation.volume | 55 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | MESSENGER-RNA EXPRESSION | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE UCP3 | - |
dc.subject.keywordPlus | FREE FATTY-ACID | - |
dc.subject.keywordPlus | GENOMIC STRUCTURE | - |
dc.subject.keywordPlus | GENETIC-VARIATION | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | POLYMORPHISM | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | VARIANTS | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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