Integrative time-serial networks for genome-wide lncRNA-mRNA interactions reveal interferon-inducible antiviral and T-cell receptor regulations against PRRSV infection
DC Field | Value | Language |
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dc.contributor.author | Lim, Byeonghwi | - |
dc.contributor.author | Kim, Seung-Chai | - |
dc.contributor.author | Kim, Won-Il | - |
dc.contributor.author | Kim, Jun-Mo | - |
dc.date.accessioned | 2023-09-06T10:40:48Z | - |
dc.date.available | 2023-09-06T10:40:48Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 0145-305X | - |
dc.identifier.issn | 1879-0089 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67446 | - |
dc.description.abstract | Porcine reproductive and respiratory syndrome virus (PRRSV) infection severely affects the swine industry each year. Although the host mechanisms against PRRSV infection have been identified in key target tissues through whole transcriptome sequencing, specific molecular regulators have not been elucidated. Long non-coding RNA (lncRNA) expression is highly specific and could thus be used to effectively identify PRRSV-specific candidates. Here, we identified novel lncRNAs in lungs, bronchial lymph nodes, and tonsils after PRRSV infection and constructed phenotype-based integrative co-expression networks using time-series differentially expressed (DE) lncRNAs and mRNAs. After the analyses, a total of 309 lncRNA-mRNA interactions were identified. During early host innate signalling, interferon-inducible and interferon genes were positively regulated by specific lncRNA. Moreover, T-cell receptor genes in lung adaptive immune signalling were negatively regulated by specific lncRNA. Collectively, our findings provide insights into the genome-wide lncRNA-mRNA interactions and dy-namic regulation of lncRNA-mediated mechanisms against PRRSV infection. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Integrative time-serial networks for genome-wide lncRNA-mRNA interactions reveal interferon-inducible antiviral and T-cell receptor regulations against PRRSV infection | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.dci.2023.104759 | - |
dc.identifier.bibliographicCitation | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, v.147 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 001022415800001 | - |
dc.identifier.scopusid | 2-s2.0-85163754606 | - |
dc.citation.title | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | - |
dc.citation.volume | 147 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Integrative network | - |
dc.subject.keywordAuthor | Interferon -inducible regulation | - |
dc.subject.keywordAuthor | Long non -coding RNA | - |
dc.subject.keywordAuthor | Porcine reproductive and respiratory syndrome | - |
dc.subject.keywordAuthor | virus | - |
dc.subject.keywordAuthor | T -cell receptor regulation | - |
dc.subject.keywordPlus | LONG NONCODING RNAS | - |
dc.subject.keywordPlus | RESPIRATORY SYNDROME | - |
dc.subject.keywordPlus | LYMPHOID ORGANS | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | PIGS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.relation.journalResearchArea | Fisheries | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalResearchArea | Zoology | - |
dc.relation.journalWebOfScienceCategory | Fisheries | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Zoology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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