Rapid Communication: MicroRNA co-expression network reveals apoptosis in the reproductive tract during molting in laying hens
DC Field | Value | Language |
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dc.contributor.author | Kim, J. | - |
dc.contributor.author | Lim, W. | - |
dc.contributor.author | Bazer, F. W. | - |
dc.contributor.author | Song, G. | - |
dc.date.accessioned | 2023-09-07T06:41:16Z | - |
dc.date.available | 2023-09-07T06:41:16Z | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 0021-8812 | - |
dc.identifier.issn | 1525-3163 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67498 | - |
dc.description.abstract | The aim of this study was to determine the regulatory mechanisms of molting and recrudescence via studying the micro-RNA (miRNA) expression in the oviduct of laying hens. We performed a cDNA microarray analysis in the magnum tissue from the oviduct to identify the whole miRNA profiles through the molting and recrudescence periods. A total of 35 laying hens (47-wk-old) were divided into 7 groups (0 d: a control group; 6 and 12 d: 2 molting-period groups fed on a high-zinc diet; and 20, 25, 30, and 35 d: 4 recrudescence-period groups fed on a normal diet after a 12-d period on a high-zinc diet). An miRNA co-expression network (miRCN) was generated using the differentially expressed miRNA (DEM) according to the entire data integration. The significantly co-expressed miRNA (n = 111) were highly differentially expressed from 12 to 20 d, which was a transition period between molting and recrudescence, while their expression patterns were contrary to the estrogen changes. The targets of highly connected miRNA (n = 12) indicated the significant biological pathways and gene ontology (GO) terms, such as MAPK and Wnt signaling and magnesium-ion binding, which are associated with apoptotic activities. These results suggest that the miRNA of the miRCN might play a role in the apoptotic progression of the reproductive tract during molting. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER SOC ANIMAL SCIENCE | - |
dc.title | Rapid Communication: MicroRNA co-expression network reveals apoptosis in the reproductive tract during molting in laying hens | - |
dc.type | Article | - |
dc.identifier.doi | 10.2527/jas2017.1972 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ANIMAL SCIENCE, v.95, no.11, pp 5100 - 5104 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000417113700035 | - |
dc.identifier.scopusid | 2-s2.0-85033773171 | - |
dc.citation.endPage | 5104 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 5100 | - |
dc.citation.title | JOURNAL OF ANIMAL SCIENCE | - |
dc.citation.volume | 95 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | co-expression network | - |
dc.subject.keywordAuthor | laying hens | - |
dc.subject.keywordAuthor | miRNA | - |
dc.subject.keywordAuthor | molting | - |
dc.subject.keywordPlus | ESTROGEN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PHYSIOLOGY | - |
dc.subject.keywordPlus | OVIDUCT | - |
dc.subject.keywordPlus | DICER | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Dairy & Animal Science | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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