Nanosome-Mediated Delivery Of Hdac Inhibitors and Oxygen Molecules for the Transcriptional Reactivation of Latent Hiv-Infected Cd4+ T Cells
DC Field | Value | Language |
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dc.contributor.author | Hong, Joohye | - |
dc.contributor.author | Choi, Yonghyun | - |
dc.contributor.author | Lee, Gahyun | - |
dc.contributor.author | Kim, Jiwon | - |
dc.contributor.author | Jang, Yeonwoo | - |
dc.contributor.author | Yoon, Cheol-Hee | - |
dc.contributor.author | Seo, Hyun Wook | - |
dc.contributor.author | Park, In-Kyu | - |
dc.contributor.author | Kang, Shin Hyuk | - |
dc.contributor.author | Choi, Jonghoon | - |
dc.date.accessioned | 2023-09-15T02:46:21Z | - |
dc.date.available | 2023-09-15T02:46:21Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.issn | 1613-6829 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67603 | - |
dc.description.abstract | The treatment of human immunodeficiency virus (HIV) infection is notoriously difficult due to the ability of this virus to remain latent in the host's CD4+ T cells. Histone deacetylases (HDACs) interfere with DNA transcription in HIV-infected hosts, resulting in viral latency. Therefore, HDAC inhibitors can be used to activate viral transcription in latently infected cells, after which the virus can be eliminated through a shock-and-kill strategy. Here, a drug delivery system is developed to effectively deliver HDAC inhibitors to latent HIV-infected cells. Given that the efficacy of HDAC inhibitors is reduced under hypoxic conditions, oxygen-containing nanosomes are used as drug carriers. Oxygen-containing nanosomes can improve the efficiency of chemotherapy by delivering essential oxygen to cells. Additionally, their phospholipid bilayer structure makes them uniquely well-suited for drug delivery. In this study, a novel drug delivery system is developed by taking advantage of the oxygen carriers in these oxygen nanosomes, incorporating a multi-drug strategy consisting of HDAC inhibitors and PKA activators, and introducing CXCR4 binding peptides to specifically target CD4+ T cells. Oxygen nanosomes with enhanced targeting capability through the introduction of the CXCR4 binding peptide mitigate drug toxicity and slow down drug release. The observed changes in the expression of p24, a capsid protein of HIV, indirectly confirm that the proposed drug delivery system can effectively induce transcriptional reactivation of HIV in latent HIV-infected cells. © 2023 Wiley-VCH GmbH. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley and Sons Inc | - |
dc.title | Nanosome-Mediated Delivery Of Hdac Inhibitors and Oxygen Molecules for the Transcriptional Reactivation of Latent Hiv-Infected Cd4+ T Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/smll.202301730 | - |
dc.identifier.bibliographicCitation | Small, v.19, no.37 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000978506700001 | - |
dc.identifier.scopusid | 2-s2.0-85154038006 | - |
dc.citation.number | 37 | - |
dc.citation.title | Small | - |
dc.citation.volume | 19 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordAuthor | CD4 <sup>+</sup> T cells | - |
dc.subject.keywordAuthor | CXCR4 | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | histone deacetylase (HDAC) inhibitors | - |
dc.subject.keywordAuthor | human immunodeficiency virus (HIV) | - |
dc.subject.keywordAuthor | liposome | - |
dc.subject.keywordAuthor | oxygen delivery | - |
dc.subject.keywordAuthor | shock-and-kill | - |
dc.subject.keywordPlus | ADENOSINE | - |
dc.subject.keywordPlus | CXCR4 | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | CCR5 | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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