Folate receptor-mediated celastrol and irinotecan combination delivery using liposomes for effective chemotherapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Soe, Zar Chi | - |
dc.contributor.author | Thapa, Raj Kumar | - |
dc.contributor.author | Ou, Wenquan | - |
dc.contributor.author | Gautam, Milan | - |
dc.contributor.author | Hanh Thuy Nguyen | - |
dc.contributor.author | Jin, Sung Giu | - |
dc.contributor.author | Ku, Sae Kwang | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Kim, Jong Oh | - |
dc.date.available | 2019-01-22T12:34:35Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.issn | 1873-4367 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/676 | - |
dc.description.abstract | Drug targeting using functionalized nanoparticles provides a new standard in anticancer therapy. Liposomes, safe and effective drug delivery carriers, can incorporate both hydrophilic and hydrophobic drugs for combination chemotherapy treatment of cancers. The objectives of the current study were to synthesize and test the effectiveness of a nanotechnology-based strategy utilizing folic acid (FA)-conjugated liposomes that incorporate both celastrol (Cs) and irinotecan (Ir) for targeted breast cancer therapy. Our results revealed the successful preparation of Cs and Ir-loaded folate-targeted liposomes (Lipo/Cs/Ir-FA) with a small particle size (similar to 190 nm) and polydispersity index (similar to 0.10). The formulation exhibited higher drug release profiles for both Ir and Cs at pH 5.0 compared to those at physiological pH, favoring cancer cell-targeted release. Furthermore, in vitro cell studies showed high uptake and enhanced apoptosis in folate receptor-positive breast cancer cells (MCF-7 and MDA-MB231), but not in folate receptor-negative lung cancer cells (A549). Moreover, an in vivo study in a mouse tumor model using MDA-MB-231 xenografts supported effective drug delivery behavior of the folate-conjugated liposomes by selective targeting of tumor tissue and minimizing systemic adverse effects. Therefore, our formulation could provide an effective therapy for targeted cancer treatment. | - |
dc.format.extent | 11 | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Folate receptor-mediated celastrol and irinotecan combination delivery using liposomes for effective chemotherapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.colsurfb.2018.07.013 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.170, pp 718 - 728 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000445989400084 | - |
dc.identifier.scopusid | 2-s2.0-85049535374 | - |
dc.citation.endPage | 728 | - |
dc.citation.startPage | 718 | - |
dc.citation.title | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.volume | 170 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Celastrol | - |
dc.subject.keywordAuthor | Folic acid | - |
dc.subject.keywordAuthor | Irinotecan | - |
dc.subject.keywordAuthor | Liposomes | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | HYBRID NANOPARTICLES | - |
dc.subject.keywordPlus | PHOTOTHERMAL THERAPY | - |
dc.subject.keywordPlus | HISTONE DEACETYLASE | - |
dc.subject.keywordPlus | ANTICANCER ACTIVITY | - |
dc.subject.keywordPlus | PLGA NANOPARTICLES | - |
dc.subject.keywordPlus | INDUCED-APOPTOSIS | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | PHASE-II | - |
dc.subject.keywordPlus | DRUG | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.