Green Tea Polyphenol Epigallocatechin-3-O-Gallate Attenuates Lipopolysaccharide-induced Nitric Oxide Production in RAW264.7 Cells
DC Field | Value | Language |
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dc.contributor.author | Seung-Jae Lee | - |
dc.contributor.author | Hyun Woo Kang | - |
dc.contributor.author | Seung Yuan Lee | - |
dc.contributor.author | Sun Jin Hur | - |
dc.date.accessioned | 2023-09-22T01:40:28Z | - |
dc.date.available | 2023-09-22T01:40:28Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2333-1119 | - |
dc.identifier.issn | 2333-1240 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67734 | - |
dc.description.abstract | Epigallocatechin-3-O-gallate (EGCG), the major polyphenol found in green tea, has been shown to downregulate inflammatory responses in macrophages; however, the underlying mechanism has not been understood. Overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) is known to be closely correlated with the pathology of a variety of diseases and inflammations. In this study, we investigated the inhibitory effect of EGCG on NO production and its molecular mechanism in lipopolysaccharide (LPS)-stimulated macrophage RAW264.7 cells. Besides a decrease in NO secretion, protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) also decreased in LPS-stimulated RAW264.7 macrophage cells treated with EGCG. These results suggest that EGCG possesses a potent anti-inflammatory activity. | - |
dc.format.extent | 4 | - |
dc.title | Green Tea Polyphenol Epigallocatechin-3-O-Gallate Attenuates Lipopolysaccharide-induced Nitric Oxide Production in RAW264.7 Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.12691/jfnr-2-7-16 | - |
dc.identifier.bibliographicCitation | Journal of Food and Nutrition Research, v.2, no.7, pp 425 - 428 | - |
dc.description.isOpenAccess | Y | - |
dc.citation.endPage | 428 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 425 | - |
dc.citation.title | Journal of Food and Nutrition Research | - |
dc.citation.volume | 2 | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Epigallocatechin-3-O-gallate | - |
dc.subject.keywordAuthor | Nitric oxide | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | RAW264.7 cells | - |
dc.subject.keywordAuthor | Lipopolysaccharide | - |
dc.description.journalRegisteredClass | foreign | - |
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