The serotype-specific prevalence of pneumococci in hospitalized pneumonia patients with COPD: a prospective, multi-center, cohort study
DC Field | Value | Language |
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dc.contributor.author | Kim, Jae Yeol | - |
dc.contributor.author | Jung, Jae-Woo | - |
dc.contributor.author | Kang, Min-Jong | - |
dc.contributor.author | Kim, Deog Kyeom | - |
dc.contributor.author | Choi, Hayoung | - |
dc.contributor.author | Cho, Young-Jae | - |
dc.contributor.author | Jang, Seung Hun | - |
dc.contributor.author | Lee, Chang-Hoon | - |
dc.contributor.author | Oh, Yeon Mok | - |
dc.contributor.author | Park, Ji Sook | - |
dc.date.accessioned | 2023-09-25T09:01:25Z | - |
dc.date.available | 2023-09-25T09:01:25Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.issn | 2005-6648 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67738 | - |
dc.description.abstract | Background/Aims: The overall incidence of pneumococcal pneumonia is declining. However, the change in the pathogenic distribution of community-acquired pneumonia (CAP) in chronic obstructive pulmonary disease (COPD) patients and the sero-type specificity of Streptococcus pneumoniae have not been evaluated in the post-era of pneumococcal vaccination in Korea.Methods: We conducted a prospective, multi-center, cohort study from seven University-affiliated hospitals. The primary objective was the identification of serotype-specific prevalence of pneumococcal pneumonia in COPD patients hospitalized for CAP. For the purpose, we conducted serotype-specific urine antigen detection (SS-UAD) assays for S. pneumoniae. The secondary objectives were other clinical characteristics of pneumonia including vaccination status.Results: The total number of participants was 349. Most of them were male (95.1%) with old ages (75.55 & PLUSMN; 8.59 y). The positive rate for S. pneumoniae was 9.2% with SS-UAD assay and the common serotypes were 22F, 6A, and 6B. In the sputum, Pseudomonas aeruginosa (5.0%) and Haemophilus influenzae (4.0%) were common pathogens. The vaccination rate was 78.8%, 53.0%, and 25.8% for influenza, pneumococcal polysaccharide vaccine 23 (PPV 23), and pneumococcal protein-conjugated vaccine 13 (PCV 13), respectively. Thirteen patients died during hospitalization (mortality rate; 3.7%). There was no difference in the respective rate of influenza vaccination (79.2% vs. 69.2%, p = 0.288) and PCV 13 vaccination (25.6% vs. 30.8%, p = 0.443) between survivors and the deceased.Conclusions: Serotypes 22F, 6A, and 6B, which are covered either by PPV 23 or by PCV 13, are still common pneumococcal serotypes in COPD pneumonia in the post-vaccination era in Korea. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN ASSOC INTERNAL MEDICINE | - |
dc.title | The serotype-specific prevalence of pneumococci in hospitalized pneumonia patients with COPD: a prospective, multi-center, cohort study | - |
dc.type | Article | - |
dc.identifier.doi | 10.3904/kjim.2023.152 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF INTERNAL MEDICINE, v.38, no.5, pp 714 - 724 | - |
dc.identifier.kciid | ART002992249 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 001051985800001 | - |
dc.identifier.scopusid | 2-s2.0-85170294838 | - |
dc.citation.endPage | 724 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 714 | - |
dc.citation.title | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.volume | 38 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Chronic obstructive pulmonary disease | - |
dc.subject.keywordAuthor | Pneumonia | - |
dc.subject.keywordAuthor | Pneumococcus | - |
dc.subject.keywordAuthor | Serotype | - |
dc.subject.keywordAuthor | Vaccination | - |
dc.subject.keywordPlus | COMMUNITY-ACQUIRED PNEUMONIA | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | HEALTH | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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