Matrix metalloproteinase-2 regulates MDA-MB-231 breast cancer cell invasion induced by active mammalian diaphanous-related formin 1
DC Field | Value | Language |
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dc.contributor.author | Kim, Daehwan | - |
dc.contributor.author | Rhee, Sangmyung | - |
dc.date.available | 2019-03-08T12:40:49Z | - |
dc.date.issued | 2016-07 | - |
dc.identifier.issn | 1791-2997 | - |
dc.identifier.issn | 1791-3004 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6774 | - |
dc.description.abstract | Mammalian diaphanous-related formin 1 (mDia1) was initially identified as a Rho GTPase effector involved in the progression of various diseases, including types of cancer. However, the precise underlying molecular mechanism of mDia1-mediated cancer cell invasion remains to be elucidated. In the present study, mDia1 expression was demonstrated to be upregulated in tissues from a number of cancer types, including kidney, prostate, and breast cancer using immunohistochemical analysis. Forced expression of a constitutively active (CA) form of mDia1 induces invasion, as measured by Transwell invasion assay, of MDA-MB-231 cells, which is a highly invasive breast cancer cell line, and this effect was markedly impaired by matrix metalloproteinase (MMP)-2 silencing. Furthermore, the present study demonstrated that overexpression of the CA form of mDia1 leads to the induction of invasive ability in MCF-7 cells, which is a non-invasive breast cancer cell line, as a result of increased MMP-2 activity. Thus, the results of the current study suggest that mDia1 is an important regulator of breast cancer cell invasion and that this effect may be mediated by MMP-2 activity. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.title | Matrix metalloproteinase-2 regulates MDA-MB-231 breast cancer cell invasion induced by active mammalian diaphanous-related formin 1 | - |
dc.type | Article | - |
dc.identifier.doi | 10.3892/mmr.2016.5282 | - |
dc.identifier.bibliographicCitation | MOLECULAR MEDICINE REPORTS, v.14, no.1, pp 277 - 282 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000379551700033 | - |
dc.identifier.scopusid | 2-s2.0-84973508213 | - |
dc.citation.endPage | 282 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 277 | - |
dc.citation.title | MOLECULAR MEDICINE REPORTS | - |
dc.citation.volume | 14 | - |
dc.type.docType | Article | - |
dc.publisher.location | 그리이스 | - |
dc.subject.keywordAuthor | formin | - |
dc.subject.keywordAuthor | mammalian diaphanous-related formin 1 | - |
dc.subject.keywordAuthor | breast cancer cells | - |
dc.subject.keywordAuthor | matrix metalloproteinase-2 | - |
dc.subject.keywordAuthor | invasion | - |
dc.subject.keywordPlus | TUMOR-CELLS | - |
dc.subject.keywordPlus | CYTOSKELETON | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | MDIA1 | - |
dc.subject.keywordPlus | INVADOPODIA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | POLARITY | - |
dc.subject.keywordPlus | MMP-2 | - |
dc.subject.keywordPlus | DIA1 | - |
dc.subject.keywordPlus | SRC | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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