Structural properties and anti-dermatitis effects of flavonoids-loaded gold nanoparticles prepared by Eupatorium japonicum
DC Field | Value | Language |
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dc.contributor.author | Xu, Xing Yue | - |
dc.contributor.author | Moon, Sung-Kwon | - |
dc.contributor.author | Kim, Jin-Kyu | - |
dc.contributor.author | Kim, Woo Jung | - |
dc.contributor.author | Kim, Yeon-Ju | - |
dc.contributor.author | Kim, Hoon | - |
dc.date.accessioned | 2023-10-24T06:40:49Z | - |
dc.date.available | 2023-10-24T06:40:49Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 1663-9812 | - |
dc.identifier.issn | 1663-9812 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/68268 | - |
dc.description.abstract | Recently, green synthesis-based nanoformulations using plants or microorganisms have attracted great interest because of their several advantages. Nanotechnology-based biological macromolecules are emerging materials with potential applications in cosmetics and medications for ameliorating and treating inflammatory skin diseases (ISDs). Eupatorium japonicum (EJ), a native Korean medicinal plant belonging to the family Asteraceae, has been traditionally used to prepare prescriptions for the treatment of various inflammatory diseases. EJ-based gold nanoparticles (EJ-AuNPs) were biosynthesized under optimal conditions and characterized their physicochemical properties using various microscopic and spectrometric techniques. Additionally, the effects of EJ-AuNPs on ISDs as well as their underlying mechanisms were investigated in the tumor necrosis factor-alpha/interferon-gamma (T+I)-induced skin HaCaT keratinocytes. The MTT and live/dead cell staining assays showed that EJ-AuNP treatment was considerably safer than EJ treatment alone in HaCaT cells. Moreover, EJ-AuNP treatment effectively suppressed the production of T+I-stimulated inflammatory cytokines (RANTES, TARC, CTACK, IL-6, and IL-8) and intracellular reactive oxygen species, and such EJ-driven anti-inflammatory effects were shown to be associated with the downregulation of intracellular mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways. The present study provides preliminary results and a valuable strategy for developing novel anti-skin dermatitis drug candidates using plant extract-based gold nanoparticles. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.title | Structural properties and anti-dermatitis effects of flavonoids-loaded gold nanoparticles prepared by Eupatorium japonicum | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fphar.2022.1055378 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN PHARMACOLOGY, v.13 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000884911700001 | - |
dc.identifier.scopusid | 2-s2.0-85141997404 | - |
dc.citation.title | FRONTIERS IN PHARMACOLOGY | - |
dc.citation.volume | 13 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | biosynthesized nanomaterial | - |
dc.subject.keywordAuthor | plant-loaded nanoparticle | - |
dc.subject.keywordAuthor | inflammatory skin disease | - |
dc.subject.keywordAuthor | chemokine | - |
dc.subject.keywordAuthor | HaCaT | - |
dc.subject.keywordAuthor | secondary metabolites | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | CHEMOKINE PRODUCTION | - |
dc.subject.keywordPlus | GREEN SYNTHESIS | - |
dc.subject.keywordPlus | KERATINOCYTES | - |
dc.subject.keywordPlus | PSORIASIS | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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