Protective effect of protocatechuic acid of Momordica charantia from memory impairment induced by amyloid beta(25-35)

Abstract

Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide (Aβ) in plaques in brain tissue. We investigated the protective effect of protocatechuic acid on active phenolic compound from Momordica charantia, on cognition impairment under in vivo AD model of ICR mice induced by Aβ25–35. The damaged abilities of recognition and memory were occurred by the injection of Aβ25–35 in brain, and then the protocatechuic acid was administered orally for 2 weeks at dose 100 and 200 mg/kg body weight. To observe protective role from impairment of memory and cognition behavioral experiments of T-maze, object cognition and Morris water maze tests were carried out. The abilities of novel object recognition and new route awareness were improved by the administration of protocatechuic acid as oral dose-dependent manner. The result on Morris water maze test indicated that the groups administered reached more quickly protocatechuic acid the hidden platform than control group suggesting improvement of spatial perception ability. The present study supports the protective role of the protocatechuic acid against impairments of memory and cognition ability induced by Aβ under AD model of ICR mice.