Effective delivery of immunosuppressive drug molecules by silica coated iron oxide nanoparticles
DC Field | Value | Language |
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dc.contributor.author | Hwang, Jang Sun | - |
dc.contributor.author | Lee, Eunwon | - |
dc.contributor.author | Kim, Jieun | - |
dc.contributor.author | Seo, Youngmin | - |
dc.contributor.author | Lee, Kwan Hong | - |
dc.contributor.author | Hong, Jong Wook | - |
dc.contributor.author | Gilad, Assaf A. | - |
dc.contributor.author | Park, Hansoo | - |
dc.contributor.author | Choi, Jonghoon | - |
dc.date.available | 2019-03-08T12:56:51Z | - |
dc.date.issued | 2016-06 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.issn | 1873-4367 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6842 | - |
dc.description.abstract | Iron oxide nanoparticles have been used in a wide range of biomedical applications, including drug delivery, molecular imaging, and cellular imaging. Various surface modifications have been applied to the particles to stabilize their surface and to give them a moiety for anchoring tags and/or drug molecules. Conventional methods of delivering immunosuppressant drugs often require a high dose of drugs to ensure therapeutic effects, but this can lead to toxic side effects. In this study, we used silica-coated iron oxide nanoparticles (IOSs) for a drug delivery application in which the nanoparticles carry the minimum amount of drug required to be effective to the target cells. IOSs could be loaded with water-insoluble immunosuppressive drug molecules (MPA: mycophenolic acid) and be used as a contrast agent for MRI. We characterized the IOSs for their physicochemical properties and found their average hydrodynamic diameter and core size to be 40.5 nm and 5 nm, respectively. Following the introduction of MPA-loaded IOSs (IOS/M), we evaluated the secretion dynamics of cytokines from peripheral blood mononuclear cells stimulated with phytohemagglutinin (PHA). The results showed that IOS/M effectively inhibited the secretion of the cytokines interleukin-2 and tumor necrosis factor a, with a minimal concentration of MPA. In conclusion, IOW may have potential applications in both efficient drug delivery and MRI. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Effective delivery of immunosuppressive drug molecules by silica coated iron oxide nanoparticles | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.colsurfb.2016.01.040 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.142, pp 290 - 296 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000375169600035 | - |
dc.identifier.scopusid | 2-s2.0-84960123324 | - |
dc.citation.endPage | 296 | - |
dc.citation.startPage | 290 | - |
dc.citation.title | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.volume | 142 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Iron oxide nanoparticles | - |
dc.subject.keywordAuthor | Mycophenolic acid | - |
dc.subject.keywordAuthor | Immunosuppressive drug | - |
dc.subject.keywordAuthor | Magnetic resonance imaging | - |
dc.subject.keywordAuthor | Drug delivery | - |
dc.subject.keywordPlus | MYCOPHENOLIC-ACID | - |
dc.subject.keywordPlus | BIOMEDICAL APPLICATIONS | - |
dc.subject.keywordPlus | MAGNETIC NANOPARTICLES | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | CONTRAST AGENTS | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | IL-2 | - |
dc.subject.keywordPlus | CYCLOSPORINE | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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