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First Detection of Enterovirus D68 in Korean Children, September 2022

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dc.contributor.authorYun, Ki Wook-
dc.contributor.authorAhn, Bin-
dc.contributor.authorChoi, Sung Hwan-
dc.contributor.authorKang, Da Yeon-
dc.contributor.authorKim, Taek Soo-
dc.contributor.authorLee, Mi Kyung-
dc.contributor.authorPark, Kyoung Un-
dc.contributor.authorChoi, Eun Hwa-
dc.date.accessioned2023-11-07T03:42:05Z-
dc.date.available2023-11-07T03:42:05Z-
dc.date.issued2023-12-
dc.identifier.issn2093-2340-
dc.identifier.issn2092-6448-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/68481-
dc.description.abstractBackground: Enterovirus D68 (EV-D68) is a re-emerging pathogen that is particularly common in children and may cause asthma-like respiratory infection and acute flaccid myelitis. However, in Korea, EV-D68 has never been reported thus far. This study aimed to identify EV-D68 from nasopharyngeal aspirates (NPAs) in Korean children with a respiratory tract infection. Materials and Methods: The EV-D68 reference strain was purchased and blindly used to assess the detection ability of three commercial and one in-house mRT-PCR kit in 2018. Then, we selected children whose specimens were positive for human rhinovirus (HRV) and/or enterovirus (EV) by Allplex mRT-PCR (Seegene, Inc., Seoul, Korea) from April to December 2022. Total RNA was extracted from NPAs, and a partial 5'-UTR gene was amplified and sequenced for the identification of HRV/EV species. Additionally, PCR targeting the VP1 gene was performed to assess EV-D68-positive NPAs, followed by sequencing. Phylogenetic analysis and comparison of amino acid sequence alignments were performed using a partial VP1 gene of our and recent international EV-D68 strains. Results: Among the mRT-PCR kits tested, only the in-house kit was able to detect EV-D68 in 2018. However, we detected three EV-D68 strains among children hospitalized with fever and/or respiratory symptoms in September - December 2022 who tested positive for EV by the Allplex kit. Two of them were healthy toddlers with lower respiratory infections accompanied by new-onset wheezing but no neurologic complications. Among 34 children with lower respiratory infection who tested positive for HRV during the same period, EV-D68 was not detected. Phylogenetic analysis revealed that the first Korean EV-D68 belonged to subclade B3. Amino acid sequence alignment of international subclade B3 EV-D68 strains also showed that our strain is genetically more related to those from Europe than those from Japan. Conclusion: We first detected EV-D68 in three Korean children who had EV detected by the Allplex mRT-PCR kit in 2022. EV-D68 also circulated in Korea in fall 2022, but the prevalence and severity seemed to be lower than those in previous reports from other countries. © 2023 Korean Society for Antimicrobial Therapy. All rights reserved.-
dc.format.extent9-
dc.language영어-
dc.language.isoENG-
dc.publisherKorean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDS-
dc.titleFirst Detection of Enterovirus D68 in Korean Children, September 2022-
dc.title.alternativeFirst Detection of Enterovirus D68 in Korean Children, September 2022-
dc.typeArticle-
dc.identifier.doi10.3947/ic.2023.0036-
dc.identifier.bibliographicCitationInfection and Chemotherapy, v.55, no.4, pp 422 - 430-
dc.identifier.kciidART003035441-
dc.description.isOpenAccessY-
dc.identifier.wosid001136731200015-
dc.identifier.scopusid2-s2.0-85171451222-
dc.citation.endPage430-
dc.citation.number4-
dc.citation.startPage422-
dc.citation.titleInfection and Chemotherapy-
dc.citation.volume55-
dc.type.docTypeArticle-
dc.publisher.location대한민국-
dc.subject.keywordAuthorChildren-
dc.subject.keywordAuthorEnterovirus D68-
dc.subject.keywordAuthorRespiratory infection-
dc.subject.keywordPlusINCREASE-
dc.subject.keywordPlusILLNESS-
dc.subject.keywordPlusSPAIN-
dc.relation.journalResearchAreaInfectious Diseases-
dc.relation.journalWebOfScienceCategoryInfectious Diseases-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClassesci-
dc.description.journalRegisteredClasskci-
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