Evidence of multiple reassortment events of feline-to-human rotaviruses based on a rare human G3P[9] rotavirus isolated from a patient with acute gastroenteritis
- Authors
- Tinh Huu Nguyen; Van Thai Than; Hien Dang Thanh; Kim, Wonyong
- Issue Date
- Jun-2016
- Publisher
- ELSEVIER SCI LTD
- Keywords
- G3P[9]; Feline; Human; Interspecies; Transmission
- Citation
- COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, v.46, pp 53 - 59
- Pages
- 7
- Journal Title
- COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
- Volume
- 46
- Start Page
- 53
- End Page
- 59
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6881
- DOI
- 10.1016/j.cimid.2016.04.003
- ISSN
- 0147-9571
1878-1667
- Abstract
- A rare human/feline-like rotavirus G3P[9] strain, CAU14-1-262, from a 2-year-old girl with severe gastroenteritis was isolated and sequenced. The 11 gene segments of the CAU14-1-262 strain possessed a novel genotype constellation, G3-P[9]-I3-R3-C3-M3-A3-N3-T1-E3-H6, which was identified for the first time. Phylogenetic analysis of this strain identified the following genome origins: VP7, VP4, VP6, VP1-VP3, NSP1, NSP2, and NSP4 genes possessed an AU-1-like genotype 3 constellation with high sequence identity to those of the feline and human/feline-like rotaviruses; NSP5 possessed a H6 lineage, with highest sequence identity to the human/feline-like E2541 strain; and the NSP3 gene possessed a Wa-like genotype 1 constellation with high sequence identity to those of the of human rotaviruses. These results provided evidence of multiple reassortment events in G3P[9] rotavirus CAU14-1-262 and possibility of feline-to-human interspecies transmission. (C) 2016 Elsevier Ltd. All rights reserved.
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