Therapeutic Nanodiamonds Containing Icariin Ameliorate the Progression of Osteoarthritis in Rats
DC Field | Value | Language |
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dc.contributor.author | Yu, Ying | - |
dc.contributor.author | Kim, Sang-Min | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Kim, Hak Jun | - |
dc.contributor.author | Kim, Jae Gyoon | - |
dc.contributor.author | Kim, Sung Eun | - |
dc.date.accessioned | 2023-12-05T10:40:32Z | - |
dc.date.available | 2023-12-05T10:40:32Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/68825 | - |
dc.description.abstract | In present study, icariin (ICA)/tannic acid (TA)-nanodiamonds (NDs) were prepared as follows. ICA was anchored to ND surfaces with absorbed TA (ICA/TA-NDs) and we evaluated their in vitro anti-inflammatory effects on lipopolysaccharide (LPS)-activated macrophages and in vivo cartilage protective effects on a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis (OA). The ICA/TA-NDs showed prolonged release of ICA from the NDs for up to 28 days in a sustained manner. ICA/TA-NDs inhibited the mRNA levels of pro-inflammatory elements, including matrix metalloproteinases-3 (MMP-3), cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), and increased the mRNA levels of anti-inflammatory factors (i.e., IL-4 and IL-10) in LPS-activated RAW 264.7 macrophages. Animal studies exhibited that intra-articular injection of ICA/TA-NDs notably suppressed levels of IL-6, MMP-3, and TNF-α and induced level of IL-10 in serum of MIA-induced OA rat models in a dose-dependent manner. Furthermore, these noticeable anti-inflammatory effects of ICA/TA-NDs remarkably contributed to the protection of the progression of MIA-induced OA and cartilage degradation, as exhibited by micro-computed tomography (micro-CT), gross findings, and histological investigations. Accordingly, in vitro and in vivo findings suggest that the prolonged ICA delivery of ICA/TA-NDs possesses an excellent latent to improve inflammation as well as defend against cartilage disorder in OA. © 2023 by the authors. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Therapeutic Nanodiamonds Containing Icariin Ameliorate the Progression of Osteoarthritis in Rats | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms242115977 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.24, no.21 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 001100309100001 | - |
dc.identifier.scopusid | 2-s2.0-85176363478 | - |
dc.citation.number | 21 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 24 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | cartilage degradation | - |
dc.subject.keywordAuthor | icariin | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | nanodiamonds | - |
dc.subject.keywordAuthor | osteoarthritis | - |
dc.subject.keywordAuthor | tannic acid | - |
dc.subject.keywordPlus | MARROW STROMAL CELLS | - |
dc.subject.keywordPlus | OSTEOGENIC DIFFERENTIATION | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSES | - |
dc.subject.keywordPlus | CHONDROCYTES | - |
dc.subject.keywordPlus | MODELS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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