Sulforaphene identified from radish (Raphanus satiuus L.) seeds possesses antimicrobial properties against multidrug-resistant bacteria and methicillin-resistant Staphylococcus aureus
DC Field | Value | Language |
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dc.contributor.author | Lim, Sooyeon | - |
dc.contributor.author | Han, Sang-Wook | - |
dc.contributor.author | Kim, Jongkee | - |
dc.date.available | 2019-03-08T12:58:00Z | - |
dc.date.issued | 2016-06 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6890 | - |
dc.description.abstract | Isothiocyanates (ITCs) are natural products produced by the hydrolysis of glucosinolates in Brassica vegetables. ITCs, such as sulforaphane (SFA), inhibit the proliferation of cancer cells and bacterial growth. Sulforaphene (SFE), one of the major ITCs in radish seeds, is chemically similar to SFA, but its antimicrobial properties have not been studied. Here, we optimised and improved SFE extraction method using preparative liquid chromatography, and demonstrated that SFE possesses broad antimicrobial activity. Strong bactericidal activity was exhibited by SFE against all strains of Helicobacter pylori. SFE specifically exhibited a strong effect against the multidrug-resistant H. pylori strain 212 with a MIC90 (0.6 mu g/mL). Methicillinresistant Staphylococcus aureus was also susceptible to SFE treatment, with MIC90 values of 12.5-25.0 mu g/mL, but not methicillin-susceptible S. aureus. This observation gives new insight into the potential of SFE as a medicinal resource in foods and has implications in the development of new functional antimicrobial agents. (c) 2016 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Sulforaphene identified from radish (Raphanus satiuus L.) seeds possesses antimicrobial properties against multidrug-resistant bacteria and methicillin-resistant Staphylococcus aureus | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jff.2016.04.005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNCTIONAL FOODS, v.24, pp 131 - 141 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000378367100014 | - |
dc.identifier.scopusid | 2-s2.0-84962909387 | - |
dc.citation.endPage | 141 | - |
dc.citation.startPage | 131 | - |
dc.citation.title | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.volume | 24 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Radish | - |
dc.subject.keywordAuthor | Sulforaphene | - |
dc.subject.keywordAuthor | Phytochemicals | - |
dc.subject.keywordAuthor | Antimicrobial activity | - |
dc.subject.keywordAuthor | Multidrug-resistant bacteria | - |
dc.subject.keywordPlus | LUNG-CANCER RISK | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI | - |
dc.subject.keywordPlus | GROWTH-INHIBITION | - |
dc.subject.keywordPlus | DETOXIFICATION ENZYMES | - |
dc.subject.keywordPlus | ANTIBACTERIAL ACTIVITY | - |
dc.subject.keywordPlus | PATHOGENIC BACTERIA | - |
dc.subject.keywordPlus | HYDROLYSIS PRODUCTS | - |
dc.subject.keywordPlus | KAIWARE DAIKON | - |
dc.subject.keywordPlus | BRASSICA-NAPUS | - |
dc.subject.keywordPlus | ISOTHIOCYANATES | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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