Enrichment of Activated Fibroblasts as a Potential Biomarker for a Non-Durable Response to Anti-Tumor Necrosis Factor Therapy in Patients with Crohn's Disease
DC Field | Value | Language |
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dc.contributor.author | Park, Soo-Kyung | - |
dc.contributor.author | Lee, Gi-Young | - |
dc.contributor.author | Kim, Sangsoo | - |
dc.contributor.author | Lee, Chil-Woo | - |
dc.contributor.author | Choi, Chang-Hwan | - |
dc.contributor.author | Kang, Sang-Bum | - |
dc.contributor.author | Kim, Tae-Oh | - |
dc.contributor.author | Chun, Jaeyoung | - |
dc.contributor.author | Cha, Jae-Myung | - |
dc.contributor.author | Im, Jong-Pil | - |
dc.contributor.author | Ahn, Kwang-Sung | - |
dc.contributor.author | Kim, Seon-Young | - |
dc.contributor.author | Kim, Min-Suk | - |
dc.contributor.author | Lee, Chang-Kyun | - |
dc.contributor.author | Park, Dong-Il | - |
dc.date.accessioned | 2024-01-08T06:28:02Z | - |
dc.date.available | 2024-01-08T06:28:02Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69248 | - |
dc.description.abstract | We investigated whether the response to anti-tumor necrosis factor (anti-TNF) treatment varied according to inflammatory tissue characteristics in Crohn's disease (CD). Bulk RNA sequencing (RNA-seq) data were obtained from inflamed and non-inflamed tissues from 170 patients with CD. The samples were clustered based on gene expression profiles using principal coordinate analysis (PCA). Cellular heterogeneity was inferred using CiberSortx, with bulk RNA-seq data. The PCA results displayed two clusters of CD-inflamed samples: one close to (Inflamed_1) and the other far away (Inflamed_2) from the non-inflamed samples. Inflamed_1 was rich in anti-TNF durable responders (DRs), and Inflamed_2 was enriched in non-durable responders (NDRs). The CiberSortx results showed that the cell fraction of activated fibroblasts was six times higher in Inflamed_2 than in Inflamed_1. Validation with public gene expression datasets (GSE16879) revealed that the activated fibroblasts were enriched in NDRs over Next, we used DRs by 1.9 times pre-treatment and 7.5 times after treatment. Fibroblast activation protein (FAP) was overexpressed in the Inflamed_2 and was also overexpressed in the NDRs in both the RISK and GSE16879 datasets. The activation of fibroblasts may play a role in resistance to anti-TNF therapy. Characterizing fibroblasts in inflamed tissues at diagnosis may help to identify patients who are likely to respond to anti-TNF therapy. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Enrichment of Activated Fibroblasts as a Potential Biomarker for a Non-Durable Response to Anti-Tumor Necrosis Factor Therapy in Patients with Crohn's Disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms241914799 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.24, no.19 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 001081209300001 | - |
dc.identifier.scopusid | 2-s2.0-85174724776 | - |
dc.citation.number | 19 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 24 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | anti-tumor necrosis factor therapy | - |
dc.subject.keywordAuthor | Crohn's disease | - |
dc.subject.keywordAuthor | activated fibroblasts | - |
dc.subject.keywordAuthor | RNA sequencing | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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