장기작용 및 속효성 벤조디아제핀 사용 후 자발적 부작용 보고양상 비교
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이주원 | - |
dc.contributor.author | 정유선 | - |
dc.contributor.author | 유승훈 | - |
dc.contributor.author | 남달리 | - |
dc.contributor.author | 정선영 | - |
dc.date.accessioned | 2024-01-08T06:29:44Z | - |
dc.date.available | 2024-01-08T06:29:44Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 2982-5954 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69277 | - |
dc.description.abstract | To assess the patterns of adverse event reports including long-acting benzodiazepines compared with short-acting. Methods: Among the individual case safety reports (ICSRs) reported to KIDS-KAERS database (KIDS-KD) between 2016 and 2020, reports for benzodiazepines were selected. Benzodiazepines were categorized into two groups (long-acting and short-acting) based on their elimination half-life of 24 hours. We compared distribution of reported adverse events following long-acting compared by short-acting benzodiazepines. For comparing patterns of reported adverse events, we adopted the criteria of signal detection: proportional reporting ratio (PRR, PRR ≥ 2, cases ≥ 3, χ2 ≥ 4), reporting odds ratio (ROR, ROR ≥ 2, cases ≥ 3, χ2 ≥ 4), and log of information component (IC, IC_low > 0). Results: Among the total of 3,047,435 ICSRs in the KIDS-KD, the number of ICSRs for long-acting benzodiazepines users was 9,490 (0.3%) and short acting benzodiazepines users was 21,179 (0.7%). The average age was 59 years old. The number of patients aged over 65 years old for long-acting and short-acting benzodiazepines was 3,687 (38.9%) and 7,953 (37.6%), respectively. Adverse events such as delusion (PRR, 2.8), gait abnormal (PRR, 2.6), hypotonia (PRR, 2.6), migraine (PRR, 5.6), or else were reported significantly higher in long-acting benzodiazepines. Conclusion: We confirmed that adverse events including gait abnormal and delusion showed higher reporting ratios in long-acting benzodiazepines compared with short-acting benzodiazepines. Therefore, caution is required when using long acting benzodiazepines. | - |
dc.format.extent | 11 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한약물역학위해관리학회 | - |
dc.title | 장기작용 및 속효성 벤조디아제핀 사용 후 자발적 부작용 보고양상 비교 | - |
dc.title.alternative | Patterns of Adverse Event Reporting for Long- and Short-Acting Benzodiazepines | - |
dc.type | Article | - |
dc.identifier.doi | 10.56142/perm.22.0017 | - |
dc.identifier.bibliographicCitation | Pharmacoepidemiology and Risk Management, v.15, no.1, pp 51 - 61 | - |
dc.identifier.kciid | ART003024314 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 61 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 51 | - |
dc.citation.title | Pharmacoepidemiology and Risk Management | - |
dc.citation.volume | 15 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Benzodiazepines | - |
dc.subject.keywordAuthor | Half-life | - |
dc.subject.keywordAuthor | Drug-related side effects and adverse reactions | - |
dc.description.journalRegisteredClass | kciCandi | - |
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