ZNF224, Kruppel like zinc finger protein, induces cell growth and apoptosis-resistance by down-regulation of p21 and p53 via miR-663a
DC Field | Value | Language |
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dc.contributor.author | Cho, Jin Gu | - |
dc.contributor.author | Park, Seho | - |
dc.contributor.author | Lim, Chae Hyun | - |
dc.contributor.author | Kim, Hong Sook | - |
dc.contributor.author | Song, Seung Yong | - |
dc.contributor.author | Roh, Tae-Young | - |
dc.contributor.author | Sung, Jong-Hyuk | - |
dc.contributor.author | Suh, Wonhee | - |
dc.contributor.author | Ham, Seok-Jin | - |
dc.contributor.author | Lim, Key-Hwan | - |
dc.contributor.author | Park, Sang Gyu | - |
dc.date.available | 2019-03-08T12:58:35Z | - |
dc.date.issued | 2016-05-24 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6930 | - |
dc.description.abstract | ZNF224 is a Kruppel-associated box-containing zinc-finger protein which represses gene transcription by interacting with various co-repressors. However, its consensus DNA sequences and target genes are not fully identified. In this study, we identified and characterized consensus DNA sequences containing 5'-CAGC-3' recognized by ZNF224 through ChIP-sequencing, which further confirmed by ELISA, SPR, qPCR, and luciferase activity assay. ZNF224 increased miR-663a transcription by binding to miR-663a promoter, which in turn binds to 3' UTR of p53 and p21 to decrease their expression. miR-663a antagonist abolished ZNF224-mediated suppression of p21 and p53, resulting in the enhanced apoptosis by CPT. The analyses using human breast ductal carcinoma tissues exhibited that the expression of ZNF224 and miR-663a was increased in cancer compared to non-cancer region. Consequently, ZNF224 increases cell survival and decreases apoptosis by decreasing the expression of p53 and p21 via miR-663a as a transcriptional activator. Taken together, we identified and characterized DNA binding element of ZNF224, and its target genes, miR-663a, which provides a novel insight in the down-regulation of p21 and p53 via miR-663a by ZNF224 in breast cancer. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.title | ZNF224, Kruppel like zinc finger protein, induces cell growth and apoptosis-resistance by down-regulation of p21 and p53 via miR-663a | - |
dc.type | Article | - |
dc.identifier.doi | 10.18632/oncotarget.8870 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.7, no.21, pp 31177 - 31190 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000377746600102 | - |
dc.identifier.scopusid | 2-s2.0-84971569515 | - |
dc.citation.endPage | 31190 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 31177 | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 7 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | ZNF224 | - |
dc.subject.keywordAuthor | miR-663a | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | p21 | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordPlus | BREAST-CANCER CELLS | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REPRESSION | - |
dc.subject.keywordPlus | FUNCTIONAL INTERACTION | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | KAP-1 | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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