Evaluation of low-dose aspirin for primary prevention of ischemic stroke among patients with diabetes: a retrospective cohort study
DC Field | Value | Language |
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dc.contributor.author | Kim, Ye-Jee | - |
dc.contributor.author | Choi, Nam-Kyong | - |
dc.contributor.author | Kim, Mi-Sook | - |
dc.contributor.author | Lee, Joongyub | - |
dc.contributor.author | Chang, Yoosoo | - |
dc.contributor.author | Seong, Jong-Mi | - |
dc.contributor.author | Jung, Sun-Young | - |
dc.contributor.author | Shin, Ju-Young | - |
dc.contributor.author | Park, Ji-Eun | - |
dc.contributor.author | Park, Byung-Joo | - |
dc.date.accessioned | 2024-01-08T06:32:51Z | - |
dc.date.available | 2024-01-08T06:32:51Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 1758-5996 | - |
dc.identifier.issn | 1758-5996 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69372 | - |
dc.description.abstract | Background: Low-dose aspirin is recommended to reduce the risk of cardiovascular disease. However, the questions with regard to primary prevention have been raised among patients with diabetes. We evaluated low-dose aspirin use for preventing ischemic stroke in patients with diabetes using a national health insurance database. Methods: Using data from the Korean Health Insurance Review and Assessment Service database from January 1, 2005, through December 31, 2009, a population-based retrospective cohort study was conducted with incident patients with diabetes aged 40 to 99 years old with the initial use of low-dose aspirin during the index period from January 1, 2006 to December 31, 2007. We matched each low-dose aspirin user to one non-user using a propensity score. The Cox proportional hazards model was used to compare the risk of hospitalization for ischemic stroke in users and nonusers of low-dose aspirin until December 31, 2009. Results: Out of 261,065 incident patients with diabetes, 15,849 (6.2%) were low-dose aspirin users. Compared to non-users, the adjusted hazard ratio (95% confidence interval) of low-dose aspirin users for hospitalization due to ischemic stroke was 1.73 (95% CI; 1.41-2.12). In a sensitivity analysis of study subjects with more than 1 year follow-up periods, slightly higher adjusted hazard ratio (1.97, 95% CI; 1.51-2.62) was observed. In the subgroup analyses, there were no significant changes in the risk of hospitalization for ischemic stroke irrespective of gender, age, or comorbidity. Conclusions: In this study of patients with diabetes, the use of low-dose aspirin showed an increased risk of hospitalization for ischemic stroke. These results suggest that low-dose aspirin use for the primary prevention of ischemic stroke should be reconsidered in patients with diabetes. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BMC | - |
dc.title | Evaluation of low-dose aspirin for primary prevention of ischemic stroke among patients with diabetes: a retrospective cohort study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s13098-015-0002-y | - |
dc.identifier.bibliographicCitation | DIABETOLOGY & METABOLIC SYNDROME, v.7 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000350253500002 | - |
dc.identifier.scopusid | 2-s2.0-84924163322 | - |
dc.citation.title | DIABETOLOGY & METABOLIC SYNDROME | - |
dc.citation.volume | 7 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Aspirin | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | Ischemic stroke | - |
dc.subject.keywordAuthor | Health insurance claims database | - |
dc.subject.keywordAuthor | Retrospective cohort study | - |
dc.subject.keywordPlus | CARDIOVASCULAR EVENTS | - |
dc.subject.keywordPlus | TYPE-2 | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | BIAS | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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