Combined vitamin C, hydrocortisone, and thiamine therapy for patients with severe pneumonia who were admitted to the intensive care unit: Propensity score-based analysis of a before-after cohort study
DC Field | Value | Language |
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dc.contributor.author | Kim, Won-Young | - |
dc.contributor.author | Jo, Eun-Jung | - |
dc.contributor.author | Eom, Jung Seop | - |
dc.contributor.author | Mok, Jeongha | - |
dc.contributor.author | Kim, Mi-Hyun | - |
dc.contributor.author | Kim, Ki Uk | - |
dc.contributor.author | Park, Hye-Kyung | - |
dc.contributor.author | Lee, Min Ki | - |
dc.contributor.author | Lee, Kwangha | - |
dc.date.accessioned | 2024-01-08T06:58:20Z | - |
dc.date.available | 2024-01-08T06:58:20Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 0883-9441 | - |
dc.identifier.issn | 1557-8615 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69450 | - |
dc.description.abstract | Purpose: To evaluate the efficacy of combined vitamin C, hydrocortisone, and thiamine in patients with severe pneumonia. Materials and methods: All consecutive patients with severe pneumonia who were treated with the vitamin C protocol (6 g of vitamin C per day) in June 2017-January 2018 (n = 53) were compared to all consecutive patients with severe pneumonia who were treated in June 2016-January 2017 (n = 46). Propensity score analysis was used to adjust for potential baseline differences between the groups. Results: In the propensity-matched cohort (n 36/group), the treated patients had significantly less hospital mortality than the control group (17% vs. 39%; P = 0.04). The vitamin C protocol associated independently with decreased mortality in propensity score-adjusted analysis (adjusted odds ratio = 0.15, 95% confidence interval = 0.04-0.56, P = 0.005). Relative to the control group, the treatment group had a significantly higher median improvement in the radiologic score at day 7 compared with baseline (4 vs. 2; P = 0.045). The vitamin C protocol did not increase the rates of acute kidney injury or superinfection. Conclusions: Combined vitamin C. hydrocortisone, and thiamine therapy may benefit patients with severe pneumonia. (C) 2018 The Authors. Published by Elsevier Inc. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.title | Combined vitamin C, hydrocortisone, and thiamine therapy for patients with severe pneumonia who were admitted to the intensive care unit: Propensity score-based analysis of a before-after cohort study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jcrc.2018.07.004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CRITICAL CARE, v.47, pp 211 - 218 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000444896900035 | - |
dc.identifier.scopusid | 2-s2.0-85049939271 | - |
dc.citation.endPage | 218 | - |
dc.citation.startPage | 211 | - |
dc.citation.title | JOURNAL OF CRITICAL CARE | - |
dc.citation.volume | 47 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Ascorbic acid | - |
dc.subject.keywordAuthor | Hydrocortisone | - |
dc.subject.keywordAuthor | Intensive care unit | - |
dc.subject.keywordAuthor | Pneumonia | - |
dc.subject.keywordAuthor | Thiamine | - |
dc.subject.keywordPlus | COMMUNITY-ACQUIRED PNEUMONIA | - |
dc.subject.keywordPlus | ACUTE LUNG INJURY | - |
dc.subject.keywordPlus | ASCORBIC-ACID | - |
dc.subject.keywordPlus | SEPTIC SHOCK | - |
dc.subject.keywordPlus | ORGAN FAILURE | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | SEPSIS | - |
dc.subject.keywordPlus | CORTICOSTEROIDS | - |
dc.subject.keywordPlus | GLUCOCORTICOIDS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Critical Care Medicine | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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