Corticosteroid outcome may be dependent of duration of use in severe COVID-19
DC Field | Value | Language |
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dc.contributor.author | Kim, Jin Hyoung | - |
dc.contributor.author | Na, Yong Sub | - |
dc.contributor.author | Lee, Song-I | - |
dc.contributor.author | Moon, Youn Young | - |
dc.contributor.author | Hwang, Beom Seuk | - |
dc.contributor.author | Baek, Ae-Rin | - |
dc.contributor.author | Kim, Won Young | - |
dc.contributor.author | Lee, Bo Young | - |
dc.contributor.author | Seong, Gil Myeong | - |
dc.contributor.author | Baek, Moon Seong | - |
dc.date.accessioned | 2024-01-08T06:59:28Z | - |
dc.date.available | 2024-01-08T06:59:28Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.issn | 2005-6648 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69499 | - |
dc.description.abstract | Background/Aims: For patients hospitalized with coronavirus disease 2019 (COVID-19) who require supplemental oxygen, the evidence of the optimal duration of corticosteroid is limited. This study aims to identify whether long-term use of cortico-steroids is associated with decreased mortality.Methods: Between February 10, 2020 and October 31, 2021, we analyzed consecutive hospitalized patients with COVID-19 with severe hypoxemia. The patients were divided into short-term (<= 14 days) and long-term (> 14 days) corticosteroid users. The primary outcome was 60-day mortality. We performed propensity score (PS) analysis to mitigate the effect of confounders and conducted Kaplan-Meier curve analysis.Results: There were 141 (52%) short-term users and 130 (48%) long-term corticosteroid users. The median age was 68 years and the median PaO2/FiO2 at admission was 158. Of the patients, 40.6% required high-flow nasal cannula, 48.3% required mechanical ventilation, and 11.1% required extracorporeal membrane oxygenation. The overall 60-day mortality rate was 23.2%, and that of patients with hospital-acquired pneumonia (HAP) was 22.9%. The Kaplan-Meier curve for 60 day survival in the PS-matched cohort showed that corticosteroid for > 14 days was associated with decreased mortality (p = 0.0033). There were no significant differences in bacteremia and HAP between the groups. An adjusted odds ratio for the risk of 60-day mortality in short-term users was 5.53 (95% confidence interval, 1.90-18.26; p = 0.003).Conclusions: For patients with severe COVID-19, long-term use of corticosteroids was associated with decreased mortality, with no increase in nosocomial complications. Corticosteroid use for > 14 days can benefit patients with severe COVID-19. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN ASSOC INTERNAL MEDICINE | - |
dc.title | Corticosteroid outcome may be dependent of duration of use in severe COVID-19 | - |
dc.type | Article | - |
dc.identifier.doi | 10.3904/kjim.2022.201 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF INTERNAL MEDICINE, v.38, no.3, pp 382 - 392 | - |
dc.identifier.kciid | ART002952637 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000969775000001 | - |
dc.identifier.scopusid | 2-s2.0-85159342862 | - |
dc.citation.endPage | 392 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 382 | - |
dc.citation.title | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.volume | 38 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | Steroids | - |
dc.subject.keywordAuthor | Oxygen inhalation therapy | - |
dc.subject.keywordAuthor | Respiration | - |
dc.subject.keywordAuthor | Artificial | - |
dc.subject.keywordAuthor | Mortality | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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