The targeted delivery of the c-Src peptide complexed with schizophyllan to macrophages inhibits polymicrobial sepsis and ulcerative colitis in mice
DC Field | Value | Language |
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dc.contributor.author | Kim, Ye-Ram | - |
dc.contributor.author | Hwang, Jang Sun | - |
dc.contributor.author | Koh, Hyun-Jung | - |
dc.contributor.author | Jang, Kiseok | - |
dc.contributor.author | Lee, Jong-Dae | - |
dc.contributor.author | Choi, Jonghoon | - |
dc.contributor.author | Yang, Chul-Su | - |
dc.date.available | 2019-03-08T12:59:01Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.issn | 1878-5905 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6958 | - |
dc.description.abstract | Hyper-inflammatory responses triggered by intracellular reactive oxygen species (ROS) can lead to a variety of diseases, including sepsis and colitis. However, the regulators of this process remain poorly defined. In this study, we demonstrate that c-Src is a negative regulator of cellular ROS generation through its binding to p47phox. This molecule also competitively inhibits the NADPH oxidase complex (NOX) assembly. Furthermore, we developed the schizophyllan (SPG)-c-Src SH3 peptide, which is a beta-1,3-glucan conjugated c-Src SH3-derived peptide composed of amino acids 91-108 and 121-140 of c-Src. The SPG-SH3 peptide has a significant therapeutic effect on mouse ROS-mediated inflammatory disease models, cecal-ligation puncture-induced sepsis, and dextran sodium sulfate-induced colitis. It does so by inhibiting the NOX subunit assembly and proinflammatory mediator production. Therefore, the SPG-SH3 peptide is a potential therapeutic agent for ROS-associated lethal inflammatory diseases. Our findings provide clues for the development of new peptide-base drugs that will target p47phox. (C) 2016 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | The targeted delivery of the c-Src peptide complexed with schizophyllan to macrophages inhibits polymicrobial sepsis and ulcerative colitis in mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2016.02.035 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.89, pp 1 - 13 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000374072500001 | - |
dc.identifier.scopusid | 2-s2.0-84959496931 | - |
dc.citation.endPage | 13 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 89 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Schizophyllan | - |
dc.subject.keywordAuthor | c-Src | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Sepsis | - |
dc.subject.keywordAuthor | Colitis | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | VIVO PROTEIN TRANSDUCTION | - |
dc.subject.keywordPlus | SMALL-MOLECULE INHIBITORS | - |
dc.subject.keywordPlus | ACUTE LUNG INJURY | - |
dc.subject.keywordPlus | NADPH OXIDASE | - |
dc.subject.keywordPlus | BETA-GLUCAN | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.subject.keywordPlus | MICROBIAL INFECTION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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