Association between endocrine-disrupting chemical mixture and metabolic indices among children, adolescents, and adults: A population-based study in Korea
DC Field | Value | Language |
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dc.contributor.author | Kim, Byungmi | - |
dc.contributor.author | Park, Bohyun | - |
dc.contributor.author | Kim, Chung Ho | - |
dc.contributor.author | Kim, Seyoung | - |
dc.contributor.author | Park, Bomi | - |
dc.date.accessioned | 2024-01-08T22:10:54Z | - |
dc.date.available | 2024-01-08T22:10:54Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 0269-7491 | - |
dc.identifier.issn | 1873-6424 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69605 | - |
dc.description.abstract | Exposure to endocrine-disrupting chemicals (EDCs) play a role in the etiology of obesity and dyslipidemia. However, few studies have analyzed the combined effects of EDC mixtures. This study explored the association between concurrent exposure to EDCs and obesity or dyslipidemia in children, adolescents, and adults. A total of 1454 children, 891 adolescents, and 3758 (for BMI) and 3424 (for TG/HDL) adults from the Korean National Environmental Health Survey 2015 to 2017 were included in this cross-sectional study. Urinary concentrations of eight phthalate metabolites, three phenols, three parabens, and one pyrethroid pesticides metabolite were quantified. Body mass index (BMI) was measured for all participants, and triglyceride (TG) and high-density lipoprotein cholesterol (HDL-c) levels were measured for adolescents and adults. Associations between combined EDC mixtures with the BMI and TG to HDL-c ratio were evaluated using Bayesian Kernel Machine Regression (BKMR). In all age groups, most of the chemical exposures, with the exception of BPF and BPS, were detected in more than 90% of participants. There were significant moderate to high correlations within phthalate metabolites and a high correlation within parabens. The BKMR showed that EDC mixtures were associated with higher BMI in both adolescents and adults, with greater significance in adults compared with adolescents, and a higher TG/HDL in male adolescents. In adolescents, MEP and MCPP drove the main effects on BMI and TG/HDL, respectively. In adults, 3PBA and BPA drove the main effects on BMI. The findings of this study suggest that exposure to EDC mixtures is associated with higher BMI and TG/HDL, and adolescence may be a critical period for EDC mixture in terms of both outcomes. Further studies are needed, but strategies to reduce EDC exposure from early life stages may be necessary to lower the risk of metabolic disease. © 2022 Elsevier Ltd | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Association between endocrine-disrupting chemical mixture and metabolic indices among children, adolescents, and adults: A population-based study in Korea | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.envpol.2022.120399 | - |
dc.identifier.bibliographicCitation | Environmental Pollution, v.315 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000880771700010 | - |
dc.identifier.scopusid | 2-s2.0-85140273230 | - |
dc.citation.title | Environmental Pollution | - |
dc.citation.volume | 315 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Bayesian kernel machine regression | - |
dc.subject.keywordAuthor | Body mass index | - |
dc.subject.keywordAuthor | Endocrine disrupting chemicals | - |
dc.subject.keywordAuthor | High-density lipoprotein cholesterol | - |
dc.subject.keywordAuthor | Mixture analysis | - |
dc.subject.keywordAuthor | Triglycerides | - |
dc.subject.keywordPlus | URINARY CONCENTRATIONS | - |
dc.subject.keywordPlus | PHTHALATE METABOLITES | - |
dc.subject.keywordPlus | CHILDHOOD OBESITY | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | BISPHENOL-A | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | VARIABILITY | - |
dc.subject.keywordPlus | PARABENS | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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