Gryllus bimaculatus-containing diets protect against dexamethasone-induced muscle atrophy, but not high-fat diet-induced obesity
DC Field | Value | Language |
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dc.contributor.author | Kim, Min Hee | - |
dc.contributor.author | Kim, Su-Jeong | - |
dc.contributor.author | Kim, Si-Hyun | - |
dc.contributor.author | Park, Woo-Jae | - |
dc.contributor.author | Han, Jung-Soon | - |
dc.date.accessioned | 2024-01-08T22:36:39Z | - |
dc.date.available | 2024-01-08T22:36:39Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 2048-7177 | - |
dc.identifier.issn | 2048-7177 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69608 | - |
dc.description.abstract | Sarcopenia and obesity are emerging as major social problems. In this study, we examined whether Gryllus bimaculatus (GB), an edible insect, prevents dexamethasone-induced muscle atrophy (sarcopenia) or high-fat diet (HFD)-induced obesity in mice. We generated a standard chow diet (SCD) + GB (85% SCD and 15% GB powder) and HFD + GB (85% HFD and 15% GB powder). SCD + GB feeding increased gains in body weight and white adipose tissue (WAT). Despite no difference in weight change between HFD + GB- and HFD-fed mice, HFD + GB feeding aggravated insulin resistance compared with HFD feeding. SCD + GB or HFD + GB feeding did not change most gene expressions in the liver and WAT but did increase MyHC1 expression in the muscle, meaning that GB increased muscle generation. Therefore, we fed SCD + GB with dexamethasone, which induces muscle degeneration. As a result, muscle fiber size increased, as did grip strength compared with dexamethasone-injected mice. In addition, SCD + GB reduced the expression of muscle degradation factors, such as atrogin1 and muscle RING-finger protein 1 (MuRF1). Furthermore, SCD + GB feeding increased Akt, mTOR, and p70S6K phosphorylation and MyHC1 expression, meaning that it may have increased protein synthesis. In conclusion, GB has great potential for inhibiting dexamethasone-induced muscle mass loss by increasing muscle protein synthesis and inhibiting muscle protein degradation. © 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. | - |
dc.format.extent | 211 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley and Sons Inc | - |
dc.title | Gryllus bimaculatus-containing diets protect against dexamethasone-induced muscle atrophy, but not high-fat diet-induced obesity | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/fsn3.3257 | - |
dc.identifier.bibliographicCitation | Food Science and Nutrition, v.11, no.6, pp 2587 - 2797 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000928796200001 | - |
dc.identifier.scopusid | 2-s2.0-85147493938 | - |
dc.citation.endPage | 2797 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2587 | - |
dc.citation.title | Food Science and Nutrition | - |
dc.citation.volume | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | dexamethasone | - |
dc.subject.keywordAuthor | edible insect | - |
dc.subject.keywordAuthor | Gryllus bimaculatus | - |
dc.subject.keywordAuthor | muscle atrophy | - |
dc.subject.keywordAuthor | sarcopenia | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | MICE | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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