Expression of mucins (MUC1, MUC2, MUC5AC and MUC6) in ALK-positive lung cancer: Comparison with EGFR-mutated lung canceropen access
- Authors
- Lee, Hong Kyu; Kwon, Mi Jung; Seo, Jinwon; Kim, Jeong Won; Hong, Mineui; Park, Hye-Rim; Min, Soo Kee; Choe, Ji-Young; Ra, Yong Joon; Jang, Seung Hun; Hwang, Yong Il; Kim, Ho Young; Min, Kyueng-Whan
- Issue Date
- Mar-2019
- Publisher
- ELSEVIER GMBH
- Keywords
- Anaplastic lymphoma kinase; Mucin; Lung cancer; Prognosis; Immunohistochemistry
- Citation
- PATHOLOGY RESEARCH AND PRACTICE, v.215, no.3, pp 459 - 465
- Pages
- 7
- Journal Title
- PATHOLOGY RESEARCH AND PRACTICE
- Volume
- 215
- Number
- 3
- Start Page
- 459
- End Page
- 465
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69711
- DOI
- 10.1016/j.prp.2018.12.011
- ISSN
- 0344-0338
- Abstract
- ALK-positive (ALK +) lung adenocarcinoma usually shows a more advanced-staged disease with frequent nodal metastasis and highly aggressive outcomes compared with EGFR-mutated lung cancers. The aim of this study was to investigate the expression profiles of several mucins in ALK + lung cancers to gain insight into the relationship between the more aggressive biological nature of ALK + lung cancers and the role of mucins. We examined the immunohistochemical profiles of mucins MUC1, MUC2, MUC5AC, and MUC6 in 19 ALK + lung cancers compared with 42 EGFR-mutated lung cancers. ALK + cancers were found to occur in younger patients and were characterized by a solid-predominant histologic subtype with frequent signet ring cells and peritumoral muciphages. By contrast, EGFR-mutated cancers lacked ALK-specific histological patterns. Although all MUC1 and MUCSAC were expressed in both subtypes, MUC1 expression in ALK + cancers was visualized exclusively through cytoplasmic staining, whereas those in EGFR-mutated cancers were predominantly membranous staining in apical area (92.9%) and focally in cytoplasmic staining (7.1%). MUCSAC expression in ALK + cancers was exclusively visualized through cytoplasmic staining (100%), whereas EGFR-mutated cancers showed predominantly perinuclear dot-like patterns (90.5%) and focal cytoplasmic staining (9.5%). MUC2 and MUC6 expression was not detected in either type of lung cancer. Conclusions: The high frequency of both MUC1 and MUC5AC cytoplasmic expression, coupled with a lack of MUC2 and MUC6 expression in ALK + lung cancer may contribute to the biologically aggressive behavior of ALK + cancer. Inhibitors to these types of mucins may thus act as a barrier to cancerous extension reducing their aggressive behavior.
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