Poorly Differentiated Clusters in Colorectal Adenocarcinomas Share Biological Similarities with Micropapillary Patterns as well as Tumor Buds
DC Field | Value | Language |
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dc.contributor.author | Hong, Mineui | - |
dc.contributor.author | Kim, Jeong Won | - |
dc.contributor.author | Shin, Mi Kyung | - |
dc.contributor.author | Kim, Byung Chun | - |
dc.date.accessioned | 2024-01-09T01:04:40Z | - |
dc.date.available | 2024-01-09T01:04:40Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69715 | - |
dc.description.abstract | In colorectal carcinoma, poorly differentiated clusters (PDCs) are a poor prognostic indicator and show morphological continuity and behavioral similarities to micropapillary patterns (MPPs) as well as tumor buds (TBs). Epithelial-mesenchymal transition (EMT) and inhibition of cancer-stromal interactions may contribute to the development of PDCs. To clarify the biological nature of PDCs, we examined immunohistochemical stainings for beta-catenin, Ki-67, E-cadherin, epithelial cell adhesion molecule (EpCAM), MUC1, and epithelial membrane antigen (EMA), which are associated with EMT and cancer-stromal interactions. The expression frequencies and patterns of PDCs, TBs, and differentiated neoplastic glands from the tumor center (TC) were compared. In the study group (117 cases), the nuclear beta-catenin staining index was higher in PDCs (37.3%) and TBs (43.3%) than in neoplastic glands from TC (8.9%, P < 0.001). The mean Ki-67 labeling index in TC was 71.5%, whereas it was decreased in PDCs (31.2%) and TBs (10.2%, P < 0.001). E-cadherin and EpCAM displayed a tendency to be found along the cell membrane in TC samples (91.5% and 92.3%, respectively), whereas they showed loss of membranous staining in PDC (44.4% and 36.8%, respectively) and TB samples (60.7% and 68.4%, respectively). An inside-out pattern for MUC1 and EMA was frequently observed in PDC (48.7% and 45.3%, respectively) and TB samples (46.2% and 45.3%, respectively), but not in TC samples. Our data demonstrate that there is a pathogenetic overlap among PDCs, TBs, and MPPs and suggest that they might represent sequential growth patterns that branch from common biological processes such as dedifferentiation and alteration in cancer-stromal interactions. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Poorly Differentiated Clusters in Colorectal Adenocarcinomas Share Biological Similarities with Micropapillary Patterns as well as Tumor Buds | - |
dc.type | Article | - |
dc.identifier.doi | 10.3346/jkms.2017.32.10.1595 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.32, no.10, pp 1595 - 1602 | - |
dc.identifier.kciid | ART002266169 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000414044100008 | - |
dc.identifier.scopusid | 2-s2.0-85029027019 | - |
dc.citation.endPage | 1602 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1595 | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 32 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Colorectal Carcinoma | - |
dc.subject.keywordAuthor | Poorly Differentiated Clusters | - |
dc.subject.keywordAuthor | Tumor Budding | - |
dc.subject.keywordAuthor | Micropapillary | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | E-CADHERIN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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