대장암종에서 HSP 70의 예후인자로서의 의의Prognostic value of HSP 70 in colorectal cancer
- Authors
- 윤상호; 차성재; 박성준; 임현묵; 박성일; 이태진; 김형중
- Issue Date
- May-2001
- Publisher
- 대한외과학회
- Keywords
- HSP 70; 대장암종 Heat shock protein; Colorectal cancer
- Citation
- 대한외과학회지, v.60, no.5, pp 531 - 535
- Pages
- 5
- Journal Title
- 대한외과학회지
- Volume
- 60
- Number
- 5
- Start Page
- 531
- End Page
- 535
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69759
- ISSN
- 2288-6575
2288-6796
- Abstract
- Purpose: To evaluate the relationships between the expression of HSP 70 and prognostic factors, including T-stage, lymph node metastasis, distant metastasis, stage, differentiation and survival rate in colorectal cancer.
Methods: We studied 62 patients with colorectal cancer in order to evaluate the relationships between the expression of HSP 70 and multiple prognostic factors, including T-stage, lymph node metastasis, distant metastasis, stage and
differentiation.
Results: There was no statistically significant correlation among HSP 70, T-stage, lymph node metastasis, distant metastasis, stage and differentiation. However, in our study, the expression of HSP 70 was slightly elevated in case with no lymph node metastasis, a lower stage and well differentiated colorectal cancer. In regards to survival, the overall survival rate was lower in the group with positive HSP 70 vice the negative group, and this was statistically significant.
Conclusion: HSP 70 expression and the prognostic factors of colorectal cancer appear not to be correlated to each other, although HSP 70 may play a certain role in colorectal cancer. Further studies are required for determining the prognostic factors in colorectal cancer.
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