Randomized multicentre trial comparing external and internal pancreatic stenting during pancreaticoduodenectomy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, J. -Y. | - |
dc.contributor.author | Chang, Y. R. | - |
dc.contributor.author | Kim, S. -W. | - |
dc.contributor.author | Choi, S. H. | - |
dc.contributor.author | Park, S. J. | - |
dc.contributor.author | Lee, S. E. | - |
dc.contributor.author | Lim, C. -S. | - |
dc.contributor.author | Kang, M. J. | - |
dc.contributor.author | Lee, H. | - |
dc.contributor.author | Heo, J. S. | - |
dc.date.available | 2019-03-08T12:59:22Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 0007-1323 | - |
dc.identifier.issn | 1365-2168 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6979 | - |
dc.description.abstract | Background: There is no consensus on the best method of preventing postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD). This multicentre, parallel group, randomized equivalence trial investigated the effect of two ways of pancreatic stenting after PD on the rate of POPF. Methods: Patients undergoing elective PD or pylorus-preserving PD with duct-to-mucosa pancreaticojejunostomy were enrolled from four tertiary referral hospitals. Randomization was stratified according to surgeon with a 1 : 1 allocation ratio to avoid any related technical factors. The primary endpoint was clinically relevant POPF rate. Secondary endpoints were nutritional index, remnant pancreatic volume, long-term complications and quality of life 2 years after PD. Results: A total of 328 patients were randomized to the external (164 patients) or internal (164) stent group between August 2010 and January 2014. The rates of clinically relevant POPF were 24.4 per cent in the external and 18.9 per cent in the internal stent group (risk difference 5.5 per cent). As the 90 per cent confidence interval (-2.0 to 13.0 per cent) did not fall within the pre-defined equivalence limits (-10 to 10 per cent), the clinically relevant POPF rates in the two groups were not equivalent. Similar results were observed for patients with soft pancreatic texture and high fistula risk score. Other postoperative outcomes were comparable between the two groups. Five stent-related complications occurred in the external stent group. Multivariable analysis revealed that soft pancreatic texture, non-pancreatic disease and high body mass index (23.3 kg/m(2) or above) predicted clinically relevant POPF. Conclusion: External stenting after PD was associated with a higher rate of clinically relevant POPF than internal stenting. Registration number: NCT01023594 (https://www.clinicaltrials.gov). | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Randomized multicentre trial comparing external and internal pancreatic stenting during pancreaticoduodenectomy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/bjs.10160 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF SURGERY, v.103, no.6, pp 668 - 675 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000374300900005 | - |
dc.identifier.scopusid | 2-s2.0-84962786753 | - |
dc.citation.endPage | 675 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 668 | - |
dc.citation.title | BRITISH JOURNAL OF SURGERY | - |
dc.citation.volume | 103 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | DUCT STENTS | - |
dc.subject.keywordPlus | SURGERY ISGPS | - |
dc.subject.keywordPlus | FISTULA RATE | - |
dc.subject.keywordPlus | PANCREATICOJEJUNOSTOMY | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | DECREASE | - |
dc.subject.keywordPlus | COMPLICATIONS | - |
dc.subject.keywordPlus | DEFINITION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | RESECTION | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.