Inhibition of BET selectively eliminates undifferentiated pluripotent stem cells
DC Field | Value | Language |
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dc.contributor.author | Im, Jung Hyun | - |
dc.contributor.author | Hwang, Seon In | - |
dc.contributor.author | Kim, Jong-Wan | - |
dc.contributor.author | Park, Soon-Jung | - |
dc.contributor.author | Kang, Kyu-ree | - |
dc.contributor.author | You, Jueng Soo | - |
dc.contributor.author | Kim, Kee Pyo | - |
dc.contributor.author | Moon, Sung-Hwan | - |
dc.contributor.author | Cha, Hyuk-Jin | - |
dc.contributor.author | Chung, Hyung-Min | - |
dc.contributor.author | Schoeler, Hans R. | - |
dc.contributor.author | Hyun, Jung Keun | - |
dc.contributor.author | Han, Dong Wook | - |
dc.date.accessioned | 2024-01-09T03:31:23Z | - |
dc.date.available | 2024-01-09T03:31:23Z | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 2095-9273 | - |
dc.identifier.issn | 2095-9281 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69814 | - |
dc.description.abstract | Embryonic stem cells (ESCs) maintain their cellular identity through the systematic regulation of master transcription factors and chromatin remodeling complexes. Recent work has shown that the unusually large-scale enhancers-namely super-enhancers (SEs), on which BRD4, a member of the bromodomain and extraterminal domain (BET) family is highly enriched-could regulate pluripotency-related transcription factors. Moreover, inhibition of BRD4 binding on SEs has been shown to induce the differentiation of ESCs. However, the underlying mechanism of BRD4 inhibition-mediated stem cell differentiation remains elusive. Here we show that both mouse and human ESCs lose their capacity for self-renewal upon treatment with JQ1, a selective inhibitor of BET family including BRD4, with rapid suppression of pluripotency-associated genes. Notably, a high concentration of JQ1 could selectively eliminate ESCs via apoptosis, without affecting the functionality of differentiated somatic cells from ESCs, suggesting that inhibition of BET may have a beneficial effect on the development of pluripotent stem cell-based cell therapy. (C) 2018 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SCIENCE PRESS | - |
dc.title | Inhibition of BET selectively eliminates undifferentiated pluripotent stem cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.scib.2018.02.023 | - |
dc.identifier.bibliographicCitation | SCIENCE BULLETIN, v.63, no.8, pp 477 - 487 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000432524200005 | - |
dc.identifier.scopusid | 2-s2.0-85044586236 | - |
dc.citation.endPage | 487 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 477 | - |
dc.citation.title | SCIENCE BULLETIN | - |
dc.citation.volume | 63 | - |
dc.type.docType | Article | - |
dc.publisher.location | 중국 | - |
dc.subject.keywordAuthor | Bromodomain and extraterminal domain (BET) | - |
dc.subject.keywordAuthor | JQ1 | - |
dc.subject.keywordAuthor | Pluripotent stem cells | - |
dc.subject.keywordPlus | CYTOTOXIC ANTIBODY | - |
dc.subject.keywordPlus | SUPER-ENHANCERS | - |
dc.subject.keywordPlus | SELF-RENEWAL | - |
dc.subject.keywordPlus | IDENTITY | - |
dc.subject.keywordPlus | BRD4 | - |
dc.subject.keywordPlus | TUMORIGENICITY | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | BROMODOMAINS | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | PRECURSORS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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